Perception and recognition memory in monkeys following lesions of area TE and perirhinal cortex - PubMed (original) (raw)

Perception and recognition memory in monkeys following lesions of area TE and perirhinal cortex

E A Buffalo et al. Learn Mem. 2000 Nov-Dec.

Abstract

Monkeys with lesions of perirhinal cortex (PR group) and monkeys with lesions of inferotemporal cortical area TE (TE group) were tested on a modified version of the delayed nonmatching to sample (DNMS) task that included very short delay intervals (0.5 sec) as well as longer delay intervals (1 min and 10 min). Lesions of the perirhinal cortex and lesions of area TE produced different patterns of impairment. The PR group learned the DNMS task as quickly as normal monkeys (N) when the delay between sample and choice was very short (0.5 sec). However, performance of the PR group, unlike that of the N group, fell to chance levels when the delay between sample and choice was lengthened to 10 min. In contrast to the PR group, the TE group was markedly impaired on the DNMS task even at the 0.5-sec delay, and three of four monkeys with TE lesions failed to acquire the task. The results provide support for the idea that perirhinal cortex is important not for perceptual processing, but for the formation and maintenance of long-term memory. Area TE is important for the perceptual processing of visual stimuli.

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Figures

Figure 1

Figure 1

Photomicrographs of representative sections through the left and right temporal lobes of monkey PR 2, whose lesion most closely approximated the intended lesion. The sections are arranged from rostral (A) to caudal (E) (also see facing page), and the lesion is indicated by arrows at each level. rs, rhinal sulcus; sts, superior temporal sulcus; TE, area TE; A, amygdala; E, entorhinal cortex; H, hippocampal region.

Figure 1

Figure 1

Photomicrographs of representative sections through the left and right temporal lobes of monkey PR 2, whose lesion most closely approximated the intended lesion. The sections are arranged from rostral (A) to caudal (E) (also see facing page), and the lesion is indicated by arrows at each level. rs, rhinal sulcus; sts, superior temporal sulcus; TE, area TE; A, amygdala; E, entorhinal cortex; H, hippocampal region.

Figure 2

Figure 2

Photomicrographs of representative sections through the left and right temporal lobes of monkey TE 4, whose lesion most closely approximated the intended lesion. The sections are arranged from rostral (A) to caudal (E) (also see next page), and the lesion is indicated by arrows at each level. The asterisk indicates a processing artifact. rs, rhinal sulcus; sts, superior temporal sulcus; PR, perirhinal cortex; A, amygdala; E, entorhinal cortex; H, hippocampal region; PH, parahippocampal cortex.

Figure 2

Figure 2

Photomicrographs of representative sections through the left and right temporal lobes of monkey TE 4, whose lesion most closely approximated the intended lesion. The sections are arranged from rostral (A) to caudal (E) (also see next page), and the lesion is indicated by arrows at each level. The asterisk indicates a processing artifact. rs, rhinal sulcus; sts, superior temporal sulcus; PR, perirhinal cortex; A, amygdala; E, entorhinal cortex; H, hippocampal region; PH, parahippocampal cortex.

Figure 3

Figure 3

(A) Initial learning of the automated visual delayed nonmatching to sample task (DNMS) at a delay of 0.5 sec by normal monkeys (N = 3), monkeys with lesions of the perirhinal cortex (PR = 4), and monkeys with lesions of area TE (TE = 4). Symbols show trials to criterion for individual monkeys. (B) Performance across delays for the normal monkeys (N = 3) and the monkeys with lesions of the perirhinal cortex (PR-4). Bars represent standard errors of the mean. (C) An expanded view of the performance of the N and PR groups at the 10-min delay. Symbols show the performance of individual monkeys.

Figure 4

Figure 4

The ventral surface of a macaque monkey brain showing the location of the perirhinal cortex (PR) and inferotemporal cortical area TE (TE). The PR forms a band of cortex along the ventromedial surface of the temporal lobe, lateral to the rhinal sulcus. Area TE is located immediately lateral to the PR and consists of a band of cortex lying primarily on the middle temporal gyrus. See Materials and Methods for a description of the boundaries of the PR and area TE.

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