The Sir2 protein family: A novel deacetylase for gene silencing and more - PubMed (original) (raw)

Review

The Sir2 protein family: A novel deacetylase for gene silencing and more

D Shore. Proc Natl Acad Sci U S A. 2000.

No abstract available

Figures

Figure 1

Molecular model for silencing at HM mating-type loci and telomeres. Silencing is initiated by DNA-binding proteins [Rap1p and origin recognition complex (ORC), or Rap1p and Ku] that cooperate to recruit SIR protein complexes. These histone-interacting SIR complexes then assemble along adjacent nucleosomal DNA, masking or in some other way altering the nearby chromatin. At telomeres, where silencing is unstable, or variegated, recruitment of SIRs is negatively regulated by the RIF proteins

Comment on

Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose.
Tanner KG, Landry J, Sternglanz R, Denu JM. Tanner KG, et al. Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14178-82. doi: 10.1073/pnas.250422697. Proc Natl Acad Sci U S A. 2000. PMID: 11106374 Free PMC article.

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The Sir2 protein family: A novel deacetylase for gene silencing and more - PubMed (original) (raw)