Natural antibodies and complement link innate and acquired immunity - PubMed (original) (raw)
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Natural antibodies and complement link innate and acquired immunity
A F Ochsenbein et al. Immunol Today. 2000 Dec.
Abstract
Natural or spontaneous antibodies are an essential part of the first line of defense against hematogenically spreading infections, including viruses. These antibodies target virus-antibody complexes and complement to the spleen. This prevents infections from reaching vital organs and enhances neutralizing antibody responses, particularly when the antibody is bound to a highly repetitive antigen.
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