Crystal deposition and osteoarthritis - PubMed (original) (raw)

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Crystal deposition and osteoarthritis

N Olmez et al. Curr Rheumatol Rep. 1999 Dec.

Abstract

Calcium-containing crystals are commonly found in osteoarthritic (OA) joints. Although most often found in advanced OA, some calcium pyrophosphate dihydrate and apatite can be present in early stages. These crystals could be factors in pathogenesis of OA and even more likely in the progression of disease. Calcium pyrophosphate dihydrate apatites and other calcium phosphates can be mitogenic, can stimulate the release of metalloproteases, and might have mechanical abrasive effects.

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