Abstinence symptoms during withdrawal from chronic marijuana use - PubMed (original) (raw)
Abstinence symptoms during withdrawal from chronic marijuana use
E M Kouri et al. Exp Clin Psychopharmacol. 2000 Nov.
Abstract
Although marijuana is the most commonly used illicit drug in the United States, it is not established whether withdrawal from chronic use results in a clinically significant abstinence syndrome. The present study was conducted to characterize symptoms associated with marijuana withdrawal following chronic use during a supervised 28-day abstinence period. Three groups of participants were studied: (a) current chronic marijuana users, (b) former chronic marijuana users who had not used marijuana for at least 6 months prior to the study, and (c) marijuana nonusers. Current users experienced significant increases in anxiety, irritability, physical tension, and physical symptoms and decreases in mood and appetite during marijuana withdrawal. These symptoms were most pronounced during the initial 10 days of abstinence, but some were present for the entire 28-day withdrawal period. These findings support the notion of a marijuana withdrawal syndrome in humans.
Similar articles
- Changes in aggressive behavior during withdrawal from long-term marijuana use.
Kouri EM, Pope HG Jr, Lukas SE. Kouri EM, et al. Psychopharmacology (Berl). 1999 Apr;143(3):302-8. doi: 10.1007/s002130050951. Psychopharmacology (Berl). 1999. PMID: 10353434 - Marijuana abstinence effects in marijuana smokers maintained in their home environment.
Budney AJ, Hughes JR, Moore BA, Novy PL. Budney AJ, et al. Arch Gen Psychiatry. 2001 Oct;58(10):917-24. doi: 10.1001/archpsyc.58.10.917. Arch Gen Psychiatry. 2001. PMID: 11576029 Clinical Trial. - Sleep architecture in adolescent marijuana and alcohol users during acute and extended abstinence.
Cohen-Zion M, Drummond SP, Padula CB, Winward J, Kanady J, Medina KL, Tapert SF. Cohen-Zion M, et al. Addict Behav. 2009 Nov;34(11):976-9. doi: 10.1016/j.addbeh.2009.05.011. Epub 2009 May 23. Addict Behav. 2009. PMID: 19505769 Free PMC article. - The marijuana withdrawal syndrome: diagnosis and treatment.
Haney M. Haney M. Curr Psychiatry Rep. 2005 Oct;7(5):360-6. doi: 10.1007/s11920-005-0036-1. Curr Psychiatry Rep. 2005. PMID: 16216154 Review. - Effects of smoked marijuana in healthy and HIV + marijuana smokers.
Haney M. Haney M. J Clin Pharmacol. 2002 Nov;42(S1):34S-40S. doi: 10.1002/j.1552-4604.2002.tb06001.x. J Clin Pharmacol. 2002. PMID: 12412834 Review.
Cited by
- Sex differences in cannabis withdrawal symptoms among treatment-seeking cannabis users.
Herrmann ES, Weerts EM, Vandrey R. Herrmann ES, et al. Exp Clin Psychopharmacol. 2015 Dec;23(6):415-21. doi: 10.1037/pha0000053. Epub 2015 Oct 12. Exp Clin Psychopharmacol. 2015. PMID: 26461168 Free PMC article. - Reducing injection intensity is associated with decreased risk for invasive bacterial infection among high-frequency injection drug users.
Islam S, Piggott DA, Moriggia A, Astemborski J, Mehta SH, Thomas DL, Kirk GD. Islam S, et al. Harm Reduct J. 2019 Jun 17;16(1):38. doi: 10.1186/s12954-019-0312-8. Harm Reduct J. 2019. PMID: 31208419 Free PMC article. - Cannabis reinforcement and dependence: role of the cannabinoid CB1 receptor.
Cooper ZD, Haney M. Cooper ZD, et al. Addict Biol. 2008 Jun;13(2):188-95. doi: 10.1111/j.1369-1600.2007.00095.x. Epub 2008 Feb 14. Addict Biol. 2008. PMID: 18279497 Free PMC article. Review. - Effects of drugs of abuse on hippocampal plasticity and hippocampus-dependent learning and memory: contributions to development and maintenance of addiction.
Kutlu MG, Gould TJ. Kutlu MG, et al. Learn Mem. 2016 Sep 15;23(10):515-33. doi: 10.1101/lm.042192.116. Print 2016 Oct. Learn Mem. 2016. PMID: 27634143 Free PMC article. Review. - Marijuana dependence: not just smoke and mirrors.
Ramesh D, Schlosburg JE, Wiebelhaus JM, Lichtman AH. Ramesh D, et al. ILAR J. 2011;52(3):295-308. doi: 10.1093/ilar.52.3.295. ILAR J. 2011. PMID: 23382144 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical