Dendritic but not somatic GABAergic inhibition is decreased in experimental epilepsy - PubMed (original) (raw)

Dendritic but not somatic GABAergic inhibition is decreased in experimental epilepsy

R Cossart et al. Nat Neurosci. 2001 Jan.

Abstract

Impaired inhibition is thought to be important in temporal lobe epilepsy (TLE), the most common form of epilepsy in adult patients. We report that, in experimental TLE, spontaneous GABAergic inhibition was increased in the soma but reduced in the dendrites of pyramidal neurons. The former resulted from the hyperactivity of somatic projecting interneurons, whereas the latter was probably due to the degeneration of a subpopulation of dendritic projecting interneurons. A deficit in dendritic inhibition could reduce seizure threshold, whereas enhanced somatic inhibition would prevent the continuous occurrence of epileptiform activity.

PubMed Disclaimer

Similar articles

• Distinct types of ionic modulation of GABA actions in pyramidal cells and interneurons during electrical induction of hippocampal seizure-like network activity.
  Fujiwara-Tsukamoto Y, Isomura Y, Imanishi M, Fukai T, Takada M. Fujiwara-Tsukamoto Y, et al. Eur J Neurosci. 2007 May;25(9):2713-25. doi: 10.1111/j.1460-9568.2007.05543.x. Epub 2007 Apr 25. Eur J Neurosci. 2007. PMID: 17459104
• Loss of GABAergic neurons in the subiculum and its functional implications in temporal lobe epilepsy.
  Knopp A, Frahm C, Fidzinski P, Witte OW, Behr J. Knopp A, et al. Brain. 2008 Jun;131(Pt 6):1516-27. doi: 10.1093/brain/awn095. Epub 2008 May 26. Brain. 2008. PMID: 18504292
• Interneurons targeting similar layers receive synaptic inputs with similar kinetics.
  Cossart R, Petanjek Z, Dumitriu D, Hirsch JC, Ben-Ari Y, Esclapez M, Bernard C. Cossart R, et al. Hippocampus. 2006;16(4):408-20. doi: 10.1002/hipo.20169. Hippocampus. 2006. PMID: 16435315
• Kainate, a double agent that generates seizures: two decades of progress.
  Ben-Ari Y, Cossart R. Ben-Ari Y, et al. Trends Neurosci. 2000 Nov;23(11):580-7. doi: 10.1016/s0166-2236(00)01659-3. Trends Neurosci. 2000. PMID: 11074268 Review.
• The vulnerability of calretinin-containing hippocampal interneurons to temporal lobe epilepsy.
  Tóth K, Maglóczky Z. Tóth K, et al. Front Neuroanat. 2014 Sep 29;8:100. doi: 10.3389/fnana.2014.00100. eCollection 2014. Front Neuroanat. 2014. PMID: 25324731 Free PMC article. Review.

Cited by

• The Kainic Acid Models of Temporal Lobe Epilepsy.
  Rusina E, Bernard C, Williamson A. Rusina E, et al. eNeuro. 2021 Apr 9;8(2):ENEURO.0337-20.2021. doi: 10.1523/ENEURO.0337-20.2021. Print 2021 Mar-Apr. eNeuro. 2021. PMID: 33658312 Free PMC article. Review.
• Predicting radiofrequency thermocoagulation surgical outcomes in refractory focal epilepsy patients using functional coupled neural mass model.
  Cai T, Lin Y, Wang G, Luo J. Cai T, et al. Front Neurol. 2024 Aug 23;15:1402004. doi: 10.3389/fneur.2024.1402004. eCollection 2024. Front Neurol. 2024. PMID: 39246608 Free PMC article.
• Microcircuits and their interactions in epilepsy: is the focus out of focus?
  Paz JT, Huguenard JR. Paz JT, et al. Nat Neurosci. 2015 Mar;18(3):351-9. doi: 10.1038/nn.3950. Nat Neurosci. 2015. PMID: 25710837 Free PMC article. Review.
• Beta and gamma frequency synchronization by dendritic gabaergic synapses and gap junctions in a network of cortical interneurons.
  Szabadics J, Lorincz A, Tamás G. Szabadics J, et al. J Neurosci. 2001 Aug 1;21(15):5824-31. doi: 10.1523/JNEUROSCI.21-15-05824.2001. J Neurosci. 2001. PMID: 11466454 Free PMC article.
• Distally directed dendrotoxicity induced by kainic Acid in hippocampal interneurons of green fluorescent protein-expressing transgenic mice.
  Oliva AA Jr, Lam TT, Swann JW. Oliva AA Jr, et al. J Neurosci. 2002 Sep 15;22(18):8052-62. doi: 10.1523/JNEUROSCI.22-18-08052.2002. J Neurosci. 2002. PMID: 12223559 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Other Literature Sources

  • The Lens - Patent Citations Database