Reduction of Ca(2+) restores uncoupled beta-adrenergic signaling in isolated perfused transgenic mouse hearts - PubMed (original) (raw)
. 2001 Jan 19;88(1):9-11.
doi: 10.1161/01.res.88.1.9.
Affiliations
- PMID: 11139467
- DOI: 10.1161/01.res.88.1.9
Reduction of [Ca(2+)](i) restores uncoupled beta-adrenergic signaling in isolated perfused transgenic mouse hearts
V B Serikov et al. Circ Res. 2001.
Abstract
The effects of alterations in calcium in the perfusion media were studied on ss-adrenergic coupling in isolated hearts from 3 different transgenic mice: cardiac-specific overexpressed alpha(1) subunit of L-type calcium channel, overexpressed Galpha(q), and phospholamban knockout. Isolated hearts from all 3 models, when studied at [Ca(2+)] of 2 mmol/L in the perfusate, showed the usual blunted or no response to ss-adrenergic stimulation. Lowering [Ca(2+)] to 0.75 to 1.5 mmol/L unloaded the hearts of calcium and restored to nearly normal the responsiveness to ss-agonist stimulation.
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