A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease - PubMed (original) (raw)
. 2000 Dec;408(6815):982-5.
doi: 10.1038/35050116.
D M Diamond, P E Gottschall, K E Ugen, C Dickey, J Hardy, K Duff, P Jantzen, G DiCarlo, D Wilcock, K Connor, J Hatcher, C Hope, M Gordon, G W Arendash
Affiliations
- PMID: 11140686
- DOI: 10.1038/35050116
A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
D Morgan et al. Nature. 2000 Dec.
Erratum in
- Nature 2001 Aug 9;412(6847):660
Abstract
Vaccinations with amyloid-beta peptide (A beta) can dramatically reduce amyloid deposition in a transgenic mouse model of Alzheimer's disease. To determine if the vaccinations had deleterious or beneficial functional consequences, we tested eight months of A beta vaccination in a different transgenic model for Alzheimer's disease in which mice develop learning deficits as amyloid accumulates. Here we show that vaccination with A beta protects transgenic mice from the learning and age-related memory deficits that normally occur in this mouse model for Alzheimer's disease. During testing for potential deleterious effects of the vaccine, all mice performed superbly on the radial-arm water-maze test of working memory. Later, at an age when untreated transgenic mice show memory deficits, the A beta-vaccinated transgenic mice showed cognitive performance superior to that of the control transgenic mice and, ultimately, performed as well as nontransgenic mice. The A beta-vaccinated mice also had a partial reduction in amyloid burden at the end of the study. This therapeutic approach may thus prevent and, possibly, treat Alzheimer's dementia.
Comment in
- Alzheimer's disease: model behaviour.
Chapman PF. Chapman PF. Nature. 2000 Dec 21-28;408(6815):915-6. doi: 10.1038/35050179. Nature. 2000. PMID: 11140660 No abstract available. - Call for Elan to publish Alzheimer's trial details.
Bishop GM, Robinson SR, Smith MA, Perry G, Atwood CS. Bishop GM, et al. Nature. 2002 Apr 18;416(6882):677. doi: 10.1038/416677d. Nature. 2002. PMID: 11961526 No abstract available.
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