Activity-dependent regulation of neuronal plasticity and self repair - PubMed (original) (raw)
Review
Activity-dependent regulation of neuronal plasticity and self repair
G Kempermann et al. Prog Brain Res. 2000.
Abstract
Plasticity is an essential characteristic of the brain: it is part of how the brain functions and is continuous while the brain interacts with the outer world. The state of activation and the level of activity of the entire organism affect the brain's plastic response. Brain plasticity has many substrates, ranging from synapses to neurites and entire cells. The production of new neurons is part of plasticity even in the adult and old brain, but under normal conditions neurogenesis only occurs in two privileged regions of the adult brain: hippocampus and olfactory system. At least in the hippocampus, physical activity stimulates neurogenesis by acting on the proliferation of neuronal stem cells. More specific functions such as learning may be able to recruit new neurons from the pool of cells with neurogenic potential. In a broader context neuronal stem cells can likely be found throughout the brain. Therefore, novel approaches to neuroregeneration will, when most effective, make use of the activity-related effects on neuronal stem cells in the adult brain to activate these stem cells in a targeted manner to enhance brain function.
Similar articles
- Adult neural stem cells and repair of the adult central nervous system.
Goh EL, Ma D, Ming GL, Song H. Goh EL, et al. J Hematother Stem Cell Res. 2003 Dec;12(6):671-9. doi: 10.1089/15258160360732696. J Hematother Stem Cell Res. 2003. PMID: 14977476 Review. - Neuronal stem cells and adult neurogenesis.
Kempermann G. Kempermann G. Ernst Schering Res Found Workshop. 2002;(35):17-28. doi: 10.1007/978-3-662-04816-0_2. Ernst Schering Res Found Workshop. 2002. PMID: 11816271 Review. No abstract available. - Regulation and function of neurogenesis in the adult vertebrate brain.
Mendez-Otero R, Zaverucha-do-Valle C, Gubert F, Freitas GR, Santiago MF. Mendez-Otero R, et al. Braz J Med Biol Res. 2005 Oct;38(10):1553-9. doi: 10.1590/s0100-879x2005001000012. Epub 2005 Sep 6. Braz J Med Biol Res. 2005. PMID: 16172748 Review. - Functional significance of adult neurogenesis.
Kempermann G, Wiskott L, Gage FH. Kempermann G, et al. Curr Opin Neurobiol. 2004 Apr;14(2):186-91. doi: 10.1016/j.conb.2004.03.001. Curr Opin Neurobiol. 2004. PMID: 15082323 Review. - Endogenous adult neural stem cells: limits and potential to repair the injured central nervous system.
Picard-Riera N, Nait-Oumesmar B, Baron-Van Evercooren A. Picard-Riera N, et al. J Neurosci Res. 2004 Apr 15;76(2):223-31. doi: 10.1002/jnr.20040. J Neurosci Res. 2004. PMID: 15048920 Review.
Cited by
- Therapeutic Application of Stem Cells in the Repair of Traumatic Brain Injury.
Adugna DG, Aragie H, Kibret AA, Belay DG. Adugna DG, et al. Stem Cells Cloning. 2022 Jul 13;15:53-61. doi: 10.2147/SCCAA.S369577. eCollection 2022. Stem Cells Cloning. 2022. PMID: 35859889 Free PMC article. Review. - Enhanced Non-Associative Long-Term Potentiation in Immature Granule Cells in the Dentate Gyrus of Adult Rats.
Simonova NA, Volgushev MA, Malyshev AY. Simonova NA, et al. Front Synaptic Neurosci. 2022 May 30;14:889947. doi: 10.3389/fnsyn.2022.889947. eCollection 2022. Front Synaptic Neurosci. 2022. PMID: 35711669 Free PMC article. - Improving Cognition with Nutraceuticals Targeting TGF-β1 Signaling.
Grasso M, Caruso G, Godos J, Bonaccorso A, Carbone C, Castellano S, Currenti W, Grosso G, Musumeci T, Caraci F. Grasso M, et al. Antioxidants (Basel). 2021 Jul 5;10(7):1075. doi: 10.3390/antiox10071075. Antioxidants (Basel). 2021. PMID: 34356309 Free PMC article. Review. - Evidences for Adult Hippocampal Neurogenesis in Humans.
Moreno-Jiménez EP, Terreros-Roncal J, Flor-García M, Rábano A, Llorens-Martín M. Moreno-Jiménez EP, et al. J Neurosci. 2021 Mar 24;41(12):2541-2553. doi: 10.1523/JNEUROSCI.0675-20.2020. J Neurosci. 2021. PMID: 33762406 Free PMC article. Review. - Regulation of Cell Cycle Entry and Exit: A Single Cell Perspective.
Coller HA. Coller HA. Compr Physiol. 2019 Dec 18;10(1):317-344. doi: 10.1002/cphy.c190014. Compr Physiol. 2019. PMID: 31853969 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources