Delayed induction and long-term effects of mild hypothermia in a focal model of transient cerebral ischemia: neurological outcome and infarct size - PubMed (original) (raw)
Delayed induction and long-term effects of mild hypothermia in a focal model of transient cerebral ischemia: neurological outcome and infarct size
C M Maier et al. J Neurosurg. 2001 Jan.
Abstract
Object: The goals of this study were to determine the effects of delaying induction of mild hypothermia (33 degrees C) after transient focal cerebral ischemia and to ascertain whether the neuroprotective effects of mild hypothermia induced during the ischemic period are sustained over time.
Methods: In the first study, rats underwent 2 hours of middle cerebral artery (MCA) occlusion. Animals in one group were maintained under normothermic conditions (N group, 23 rats) throughout the period of ischemia and reperfusion. Rats in four additional groups were exposed to 2 hours of hypothermia, which commenced at ischemia onset (H0 group, 11 rats) or with delays of 90 (H90 group, 10 rats), 120 (H120 group, 10 rats), or 180 (H180 group, five rats) minutes, and allowed to survive for 3 days. In the second study, animals underwent 1.5 hours of MCA occlusion and were maintained under normothermic (48 rats) or hypothermic (44 rats) conditions during the ischemia period, after which they survived for 3 days, 1 week, or 2 months. All animals were evaluated for neurological findings at 24 hours and 48 hours postischemia and before they were killed. Regions of infarct were determined by examining hematoxylin and eosinstained brain slices obtained at six coronal levels.
Conclusions: Mild hypothermia conferred significant degrees of neuroprotection in terms of survival, behavioral deficits, and histopathological changes, even when its induction was delayed by 120 minutes after onset of MCA occlusion (p < 0.05) compared with normothermic conditions. Furthermore, the neuroprotective effect of mild hypothermia (2-hour duration) that was induced during the ischemia period was sustained over 2 months. These studies lend further support to the use of mild hypothermia in the treatment of stroke.
Similar articles
- Therapeutic time window of hypothermia is broader than cerebral artery flushing in carotid saline infusion after transient focal ischemic stroke in rats.
Ji Y, Hu Y, Wu Y, Ji Z, Song W, Wang S, Pan S. Ji Y, et al. Neurol Res. 2012 Sep;34(7):657-63. doi: 10.1179/1743132812Y.0000000061. Epub 2012 Jun 16. Neurol Res. 2012. PMID: 22709718 - Delayed induction of mild hypothermia to reduce infarct volume after temporary middle cerebral artery occlusion in rats.
Karibe H, Chen J, Zarow GJ, Graham SH, Weinstein PR. Karibe H, et al. J Neurosurg. 1994 Jan;80(1):112-9. doi: 10.3171/jns.1994.80.1.0112. J Neurosurg. 1994. PMID: 8270997 - Effect of mild hypothermia on focal cerebral ischemia. Review of experimental studies.
Miyazawa T, Tamura A, Fukui S, Hossmann KA. Miyazawa T, et al. Neurol Res. 2003 Jul;25(5):457-64. doi: 10.1179/016164103101201850. Neurol Res. 2003. PMID: 12866192 Review. - Drug-induced hypothermia by 5HT1A agonists provide neuroprotection in experimental stroke: new perspectives for acute patient treatment.
Johansen FF, Hasseldam H, Nybro Smith M, Rasmussen RS. Johansen FF, et al. J Stroke Cerebrovasc Dis. 2014 Nov-Dec;23(10):2879-2887. doi: 10.1016/j.jstrokecerebrovasdis.2014.07.019. Epub 2014 Oct 11. J Stroke Cerebrovasc Dis. 2014. PMID: 25307429 Review.
Cited by
- FasL shedding is reduced by hypothermia in experimental stroke.
Liu L, Kim JY, Koike MA, Yoon YJ, Tang XN, Ma H, Lee H, Steinberg GK, Lee JE, Yenari MA. Liu L, et al. J Neurochem. 2008 Jul;106(2):541-50. doi: 10.1111/j.1471-4159.2008.05411.x. Epub 2008 Apr 12. J Neurochem. 2008. PMID: 18410517 Free PMC article. - Prevention and intervention studies with telmisartan, ramipril and their combination in different rat stroke models.
Thoene-Reineke C, Rumschüssel K, Schmerbach K, Krikov M, Wengenmayer C, Godes M, Mueller S, Villringer A, Steckelings U, Namsolleck P, Unger T. Thoene-Reineke C, et al. PLoS One. 2011;6(8):e23646. doi: 10.1371/journal.pone.0023646. Epub 2011 Aug 25. PLoS One. 2011. PMID: 21901125 Free PMC article. - Hypothermia as a cytoprotective strategy in ischemic tissue injury.
Tang XN, Yenari MA. Tang XN, et al. Ageing Res Rev. 2010 Jan;9(1):61-8. doi: 10.1016/j.arr.2009.10.002. Epub 2009 Oct 13. Ageing Res Rev. 2010. PMID: 19833233 Free PMC article. Review. - Reperfusion injury following cerebral ischemia: pathophysiology, MR imaging, and potential therapies.
Pan J, Konstas AA, Bateman B, Ortolano GA, Pile-Spellman J. Pan J, et al. Neuroradiology. 2007 Feb;49(2):93-102. doi: 10.1007/s00234-006-0183-z. Epub 2006 Dec 20. Neuroradiology. 2007. PMID: 17177065 Free PMC article. Review. - The cerebral circulation and cerebrovascular disease III: Stroke.
Chandra A, Stone CR, Du X, Li WA, Huber M, Bremer R, Geng X, Ding Y. Chandra A, et al. Brain Circ. 2017 Apr-Jun;3(2):66-77. doi: 10.4103/bc.bc_12_17. Epub 2017 Jul 18. Brain Circ. 2017. PMID: 30276307 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical