Legionella and community-acquired pneumonia: a review of current diagnostic tests from a clinician's viewpoint - PubMed (original) (raw)
Review
Legionella and community-acquired pneumonia: a review of current diagnostic tests from a clinician's viewpoint
G W Waterer et al. Am J Med. 2001 Jan.
Abstract
Many physicians are unaware of the limitations of the available tests for diagnosing infections with Legionella organisms. Geographic differences in the importance of nonpneumophila Legionella species as pathogens are underrecognized, in part because available diagnostic tests are biased toward the detection of pneumophila serogroup 1. Routine laboratory practices reduce the likelihood of culturing Legionella species from clinical isolates. Failure of seroconversion is common, particularly with nonpneumophila species; even when seroconversion occurs, it may take much longer than 4 weeks. Urinary antigen testing has insufficient sensitivity to affect clinical management in most regions of the United States, as it can reliably detect only L. pneumophila serogroup 1 infections. Polymerase chain reaction-based techniques offer hope of providing highly sensitive, rapid diagnostic tests for all Legionella species, but limitations in the current tests will make validating them difficult.
Comment in
- Legionella pneumophila serogroup 1 antigen can be detected in sputum samples by an immunochromatographic assay.
Strålin K, Alriksson I, Törnqvist E. Strålin K, et al. J Clin Microbiol. 2004 Jul;42(7):3377. doi: 10.1128/JCM.42.7.3377.2004. J Clin Microbiol. 2004. PMID: 15243123 Free PMC article. No abstract available.
Similar articles
- Diagnostic and typing methods for investigating Legionella infection.
Blyth CC, Adams DN, Chen SC. Blyth CC, et al. N S W Public Health Bull. 2009 Sep-Oct;20(9-10):157-61. doi: 10.1071/nb08062. N S W Public Health Bull. 2009. PMID: 19917208 Review. - Potential importance of Legionella species as etiologies in community acquired pneumonia (CAP).
McNally C, Hackman B, Fields BS, Plouffe JF. McNally C, et al. Diagn Microbiol Infect Dis. 2000 Oct;38(2):79-82. doi: 10.1016/s0732-8893(00)00181-4. Diagn Microbiol Infect Dis. 2000. PMID: 11035237 - Distribution of Legionella species and serogroups in patients with culture-confirmed Legionella pneumonia.
Miyashita N, Higa F, Aoki Y, Kikuchi T, Seki M, Tateda K, Maki N, Uchino K, Ogasawara K, Kiyota H, Watanabe A. Miyashita N, et al. J Infect Chemother. 2020 May;26(5):411-417. doi: 10.1016/j.jiac.2019.12.016. Epub 2020 Feb 18. J Infect Chemother. 2020. PMID: 32081644 - Legionella spp.: community acquired and nosocomial infections.
Roig J, Sabria M, Pedro-Botet ML. Roig J, et al. Curr Opin Infect Dis. 2003 Apr;16(2):145-51. doi: 10.1097/00001432-200304000-00011. Curr Opin Infect Dis. 2003. PMID: 12734447 Review.
Cited by
- [Guidelines for the management of community pneumonia in adult who needs hospitalization].
Álvarez-Rocha L, Alós JI, Blanquer J, Álvarez-Lerma F, Garau J, Guerrero A, Torres A, Cobo J, Jordá R, Menéndez R, Olaechea P, Rodríguez de Castro F; Grupo de Estudio de la Neumonía Comunitaria Grave. Álvarez-Rocha L, et al. Med Intensiva. 2005 Feb;29(1):21-62. doi: 10.1016/S0210-5691(05)74199-1. Epub 2009 Jan 6. Med Intensiva. 2005. PMID: 38620135 Free PMC article. Spanish. - Urinary Antigen Testing for Respiratory Infections: Current Perspectives on Utility and Limitations.
Kim P, Deshpande A, Rothberg MB. Kim P, et al. Infect Drug Resist. 2022 Apr 27;15:2219-2228. doi: 10.2147/IDR.S321168. eCollection 2022. Infect Drug Resist. 2022. PMID: 35510157 Free PMC article. Review. - New Insight regarding Legionella Non-Pneumophila Species Identification: Comparison between the Traditional mip Gene Classification Scheme and a Newly Proposed Scheme Targeting the rpoB Gene.
Pascale MR, Salaris S, Mazzotta M, Girolamini L, Fregni Serpini G, Manni L, Grottola A, Cristino S. Pascale MR, et al. Microbiol Spectr. 2021 Dec 22;9(3):e0116121. doi: 10.1128/Spectrum.01161-21. Epub 2021 Dec 15. Microbiol Spectr. 2021. PMID: 34908503 Free PMC article. - Efficacy of PCR Analysis of Mip, Doth and Gspd Genes with Culture in Detection of Legionella pneumophila.
Bagheri H, Khaledi A, Ghanizadeh G, Esmaeili D. Bagheri H, et al. Iran J Public Health. 2021 May;50(5):1079-1081. doi: 10.18502/ijph.v50i5.6130. Iran J Public Health. 2021. PMID: 34183971 Free PMC article. No abstract available. - Legionnaires' Disease on the Rise in Switzerland: A Denominator-Based Analysis of National Diagnostic Data, 2007-2016.
Fischer FB, Schmutz C, Gaia V, Mäusezahl D. Fischer FB, et al. Int J Environ Res Public Health. 2020 Oct 8;17(19):7343. doi: 10.3390/ijerph17197343. Int J Environ Res Public Health. 2020. PMID: 33050023 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources