The digestion rate of protein is an independent regulating factor of postprandial protein retention - PubMed (original) (raw)
The digestion rate of protein is an independent regulating factor of postprandial protein retention
M Dangin et al. Am J Physiol Endocrinol Metab. 2001 Feb.
Free article
Abstract
To evaluate the importance of protein digestion rate on protein deposition, we characterized leucine kinetics after ingestion of "protein" meals of identical amino acid composition and nitrogen contents but of different digestion rates. Four groups of five or six young men received an L-[1-13C]leucine infusion and one of the following 30-g protein meals: a single meal of slowly digested casein (CAS), a single meal of free amino acid mimicking casein composition (AA), a single meal of rapidly digested whey proteins (WP), or repeated meals of whey proteins (RPT-WP) mimicking slow digestion rate. Comparisons were made between "fast" (AA, WP) and "slow" (CAS, RPT-WP) meals of identical amino acid composition (AA vs. CAS, and WP vs. RPT-WP). The fast meals induced a strong, rapid, and transient increase of aminoacidemia, leucine flux, and oxidation. After slow meals, these parameters increased moderately but durably. Postprandial leucine balance over 7 h was higher after the slow than after the fast meals (CAS: 38 +/- 13 vs. AA: -12 +/- 11, P < 0.01; RPT-WP: 87 +/- 25 vs. WP: 6 +/- 19 micromol/kg, P < 0.05). Protein digestion rate is an independent factor modulating postprandial protein deposition.
Similar articles
- Slow and fast dietary proteins differently modulate postprandial protein accretion.
Boirie Y, Dangin M, Gachon P, Vasson MP, Maubois JL, Beaufrère B. Boirie Y, et al. Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14930-5. doi: 10.1073/pnas.94.26.14930. Proc Natl Acad Sci U S A. 1997. PMID: 9405716 Free PMC article. - The rate of protein digestion affects protein gain differently during aging in humans.
Dangin M, Guillet C, Garcia-Rodenas C, Gachon P, Bouteloup-Demange C, Reiffers-Magnani K, Fauquant J, Ballèvre O, Beaufrère B. Dangin M, et al. J Physiol. 2003 Jun 1;549(Pt 2):635-44. doi: 10.1113/jphysiol.2002.036897. Epub 2003 Mar 28. J Physiol. 2003. PMID: 12665610 Free PMC article. - Influence of the protein digestion rate on protein turnover in young and elderly subjects.
Dangin M, Boirie Y, Guillet C, Beaufrère B. Dangin M, et al. J Nutr. 2002 Oct;132(10):3228S-33S. doi: 10.1093/jn/131.10.3228S. J Nutr. 2002. PMID: 12368423 Review. - Ingestion of Casein in a Milk Matrix Modulates Dietary Protein Digestion and Absorption Kinetics but Does Not Modulate Postprandial Muscle Protein Synthesis in Older Men.
Churchward-Venne TA, Snijders T, Linkens AM, Hamer HM, van Kranenburg J, van Loon LJ. Churchward-Venne TA, et al. J Nutr. 2015 Jul;145(7):1438-45. doi: 10.3945/jn.115.213710. Epub 2015 May 27. J Nutr. 2015. PMID: 26019248 Clinical Trial. - Milk proteins: Processing, gastric coagulation, amino acid availability and muscle protein synthesis.
Horstman AMH, Huppertz T. Horstman AMH, et al. Crit Rev Food Sci Nutr. 2023;63(30):10267-10282. doi: 10.1080/10408398.2022.2078782. Epub 2022 May 25. Crit Rev Food Sci Nutr. 2023. PMID: 35611879 Review.
Cited by
- Nutritional Management of Phenylketonuria.
Macleod EL, Ney DM. Macleod EL, et al. Ann Nestle Eng. 2010 Jun;68(2):58-69. doi: 10.1159/000312813. Ann Nestle Eng. 2010. PMID: 22475869 Free PMC article. - Positive muscle protein net balance and differential regulation of atrogene expression after resistance exercise and milk protein supplementation.
Reitelseder S, Agergaard J, Doessing S, Helmark IC, Schjerling P, van Hall G, Kjaer M, Holm L. Reitelseder S, et al. Eur J Nutr. 2014 Feb;53(1):321-33. doi: 10.1007/s00394-013-0530-x. Epub 2013 May 3. Eur J Nutr. 2014. PMID: 23640273 - International Society of Sports Nutrition position stand: protein and exercise.
Campbell B, Kreider RB, Ziegenfuss T, La Bounty P, Roberts M, Burke D, Landis J, Lopez H, Antonio J. Campbell B, et al. J Int Soc Sports Nutr. 2007 Sep 26;4:8. doi: 10.1186/1550-2783-4-8. J Int Soc Sports Nutr. 2007. PMID: 17908291 Free PMC article. - Whey protein supplementation for the preservation of mass and muscular strength of patients with heart failure: study protocol for a randomized controlled trial.
Dos Santos EM, de Moraes R, Tibiriça EV, Huguenin GVB, Moreira ASB, De Lorenzo AR. Dos Santos EM, et al. Trials. 2018 Aug 8;19(1):431. doi: 10.1186/s13063-018-2811-4. Trials. 2018. PMID: 30089525 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical