Studies using leukemia inhibitory factor (LIF) knockout mice and a LIF adenoviral vector demonstrate a key anti-inflammatory role for this cytokine in cutaneous inflammation - PubMed (original) (raw)

Studies using leukemia inhibitory factor (LIF) knockout mice and a LIF adenoviral vector demonstrate a key anti-inflammatory role for this cytokine in cutaneous inflammation

M Zhu et al. J Immunol. 2001.

Abstract

Previous work has implicated the cytokine leukemia inhibitory factor (LIF) in cutaneous inflammation, although results have differed as to whether LIF is pro- or anti-inflammatory in this setting. We examined edema, inflammatory cell infiltration, and cytokine responses following CFA injection in the adult mouse footpad. Inflammatory cell infiltration and edema are significantly enhanced when CFA is injected in LIF knockout mice as compared with injection of wild-type littermates. Moreover, local injection of an adenoviral vector encoding LIF suppresses both measures of inflammation. In contrast, injection of an adenoviral vector encoding beta-galactosidase has no discernable effect on inflammation. In addition, comparison of the CFA responses in LIF knockout vs wild-type skin reveals that LIF is an important regulator of IL-1beta, IL-6, IL-7, IL-2Ralpha, and IFN-gamma in cutaneous inflammation. These and our previous data indicate that both endogenous and exogenous LIF are anti-inflammatory in the CFA model and that LIF is a key regulator of the cytokine cascade. The results also indicate that adenoviral gene delivery can be an effective therapeutic approach in this paradigm.

PubMed Disclaimer

Cited by

Leukemia inhibitory factor promotes neural stem cell self-renewal in the adult brain.
Bauer S, Patterson PH. Bauer S, et al. J Neurosci. 2006 Nov 15;26(46):12089-99. doi: 10.1523/JNEUROSCI.3047-06.2006. J Neurosci. 2006. PMID: 17108182 Free PMC article.
Chronic Chlamydia infection in human organoids increases stemness and promotes age-dependent CpG methylation.
Kessler M, Hoffmann K, Fritsche K, Brinkmann V, Mollenkopf HJ, Thieck O, Teixeira da Costa AR, Braicu EI, Sehouli J, Mangler M, Berger H, Meyer TF. Kessler M, et al. Nat Commun. 2019 Mar 18;10(1):1194. doi: 10.1038/s41467-019-09144-7. Nat Commun. 2019. PMID: 30886143 Free PMC article.
Exogenous leukemia inhibitory factor stimulates oligodendrocyte progenitor cell proliferation and enhances hippocampal remyelination.
Deverman BE, Patterson PH. Deverman BE, et al. J Neurosci. 2012 Feb 8;32(6):2100-9. doi: 10.1523/JNEUROSCI.3803-11.2012. J Neurosci. 2012. PMID: 22323722 Free PMC article.
Denervated Schwann cells attract macrophages by secretion of leukemia inhibitory factor (LIF) and monocyte chemoattractant protein-1 in a process regulated by interleukin-6 and LIF.
Tofaris GK, Patterson PH, Jessen KR, Mirsky R. Tofaris GK, et al. J Neurosci. 2002 Aug 1;22(15):6696-703. doi: 10.1523/JNEUROSCI.22-15-06696.2002. J Neurosci. 2002. PMID: 12151548 Free PMC article.
Herpesvirus-encoded microRNAs detected in human gingiva alter host cell transcriptome and regulate viral infection.
Naqvi AR, Seal A, Shango J, Brambila MF, Martinez G, Chapa G, Hasan S, Yadavalli T, Jaishankar D, Shukla D, Nares S. Naqvi AR, et al. Biochim Biophys Acta Gene Regul Mech. 2018 May;1861(5):497-508. doi: 10.1016/j.bbagrm.2018.03.001. Epub 2018 Mar 15. Biochim Biophys Acta Gene Regul Mech. 2018. PMID: 29550353 Free PMC article.

Studies using leukemia inhibitory factor (LIF) knockout mice and a LIF adenoviral vector demonstrate a key anti-inflammatory role for this cytokine in cutaneous inflammation - PubMed (original) (raw)