The immunoglobulin G heavy chain repertoire in multiple sclerosis plaques is distinct from the heavy chain repertoire in peripheral blood lymphocytes - PubMed (original) (raw)
Comparative Study
The immunoglobulin G heavy chain repertoire in multiple sclerosis plaques is distinct from the heavy chain repertoire in peripheral blood lymphocytes
G P Owens et al. Clin Immunol. 2001 Feb.
Abstract
Analyses have shown that the repertoire of Ig heavy chain sequences (VH) expressed in multiple sclerosis (MS) plaques or cerebrospinal fluid is consistent with B cell clonal expansion and affinity maturation. PCR amplification of VH sequences from MS lesions obtained from an acute MS patient at autopsy revealed oligoclonal and extensively mutated VH sequences from plaque-periplaque regions with discrete intraclonal differences indicative of B cell clonal expansion in the groups of overrepresented major sequences. None of the VH sequences expressed in plaque regions were detected in peripheral blood lymphocytes from this patient. These data indicate the presence of a CNS-targeted antigen-driven response in MS plaques.
Copyright 2000 Academic Press.
Similar articles
- B cell repertoire diversity and clonal expansion in multiple sclerosis brain lesions.
Baranzini SE, Jeong MC, Butunoi C, Murray RS, Bernard CC, Oksenberg JR. Baranzini SE, et al. J Immunol. 1999 Nov 1;163(9):5133-44. J Immunol. 1999. PMID: 10528220 - Single-cell repertoire analysis demonstrates that clonal expansion is a prominent feature of the B cell response in multiple sclerosis cerebrospinal fluid.
Owens GP, Ritchie AM, Burgoon MP, Williamson RA, Corboy JR, Gilden DH. Owens GP, et al. J Immunol. 2003 Sep 1;171(5):2725-33. doi: 10.4049/jimmunol.171.5.2725. J Immunol. 2003. PMID: 12928426 - Accumulation of clonally related B lymphocytes in the cerebrospinal fluid of multiple sclerosis patients.
Colombo M, Dono M, Gazzola P, Roncella S, Valetto A, Chiorazzi N, Mancardi GL, Ferrarini M. Colombo M, et al. J Immunol. 2000 Mar 1;164(5):2782-9. doi: 10.4049/jimmunol.164.5.2782. J Immunol. 2000. PMID: 10679121 - VH-gene representation in autoantibodies reflects the normal human B-cell repertoire.
Stewart AK, Huang C, Long AA, Stollar BD, Schwartz RS. Stewart AK, et al. Immunol Rev. 1992 Aug;128:101-22. doi: 10.1111/j.1600-065x.1992.tb00834.x. Immunol Rev. 1992. PMID: 1427920 Review. - The expressed heavy chain V gene repertoire of circulating B cells in normal adults.
Stollar BD. Stollar BD. Ann N Y Acad Sci. 1995 Sep 29;764:265-74. doi: 10.1111/j.1749-6632.1995.tb55836.x. Ann N Y Acad Sci. 1995. PMID: 7486534 Review. No abstract available.
Cited by
- Next Generation Sequencing of Cerebrospinal Fluid B Cell Repertoires in Multiple Sclerosis and Other Neuro-Inflammatory Diseases-A Comprehensive Review.
Ruschil C, Kemmerer CL, Beller L, Gabernet G, Kowarik MC. Ruschil C, et al. Diagnostics (Basel). 2021 Oct 11;11(10):1871. doi: 10.3390/diagnostics11101871. Diagnostics (Basel). 2021. PMID: 34679570 Free PMC article. Review. - Animal models of Multiple Sclerosis.
Procaccini C, De Rosa V, Pucino V, Formisano L, Matarese G. Procaccini C, et al. Eur J Pharmacol. 2015 Jul 15;759:182-91. doi: 10.1016/j.ejphar.2015.03.042. Epub 2015 Mar 27. Eur J Pharmacol. 2015. PMID: 25823807 Free PMC article. Review. - The antibody genetics of multiple sclerosis: comparing next-generation sequencing to sanger sequencing.
Rounds WH, Ligocki AJ, Levin MK, Greenberg BM, Bigwood DW, Eastman EM, Cowell LG, Monson NL. Rounds WH, et al. Front Neurol. 2014 Sep 16;5:166. doi: 10.3389/fneur.2014.00166. eCollection 2014. Front Neurol. 2014. PMID: 25278930 Free PMC article. - Modeling the heterogeneity of multiple sclerosis in animals.
Simmons SB, Pierson ER, Lee SY, Goverman JM. Simmons SB, et al. Trends Immunol. 2013 Aug;34(8):410-22. doi: 10.1016/j.it.2013.04.006. Epub 2013 May 21. Trends Immunol. 2013. PMID: 23707039 Free PMC article. Review. - Targeting B cells in the treatment of multiple sclerosis: recent advances and remaining challenges.
Lehmann-Horn K, Kronsbein HC, Weber MS. Lehmann-Horn K, et al. Ther Adv Neurol Disord. 2013 May;6(3):161-73. doi: 10.1177/1756285612474333. Ther Adv Neurol Disord. 2013. PMID: 23634189 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical