Ribosome fidelity: tRNA discrimination, proofreading and induced fit - PubMed (original) (raw)

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Ribosome fidelity: tRNA discrimination, proofreading and induced fit

M V Rodnina et al. Trends Biochem Sci. 2001 Feb.

Abstract

The ribosome selects aminoacyl-tRNAs with high fidelity. Kinetic studies reveal that codon-anticodon recognition both stabilizes aminoacyl-tRNA binding on the ribosome and accelerates reactions of the productive pathway, indicating an important contribution of induced fit to substrate selection. Similar mechanisms are used by other template-programmed enzymes, such as DNA and RNA polymerases.

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