DC-STAMP, a novel multimembrane-spanning molecule preferentially expressed by dendritic cells - PubMed (original) (raw)
DC-STAMP, a novel multimembrane-spanning molecule preferentially expressed by dendritic cells
F C Hartgers et al. Eur J Immunol. 2000 Dec.
Free article
Abstract
Dendritic cells (DC) are unique in their ability to present antigen to naive T cells, and therefore play a central role in the initiation of immune responses. Characterization of DC-specific genes may help to unravel the mechanism underlying their potent antigen presenting capacity. Here we describe the identification of a novel transcript, isolated by random sequencing of a cDNA library prepared from monocyte-derived DC, which we termed DC-specific transmembrane protein (DC-STAMP). DC-STAMP is specifically expressed by DC, and not in a panel of other leukocytes or non-hematopoietic cells. Interestingly, DC-STAMP was also detected in activated but not resting blood DC. The DC-STAMP transcript encodes a 470-amino acid protein containing seven putative transmembrane domains. Expression of a DC-STAMP-GFP fusion protein in 293 cells indicates that DC-STAMP is expressed at the cell surface, and has an intracellular C terminus. Surprisingly, no sequence homology was found with any other protein or multimembrane-spanning receptor. Therefore, we propose that DC-STAMP is a novel DC-specific multimembrane-spanning protein, representing a new group of transmembrane proteins.
Similar articles
- The dendritic cell-derived protein DC-STAMP is highly conserved and localizes to the endoplasmic reticulum.
Eleveld-Trancikova D, Triantis V, Moulin V, Looman MW, Wijers M, Fransen JA, Lemckert AA, Havenga MJ, Figdor CG, Janssen RA, Adema GJ. Eleveld-Trancikova D, et al. J Leukoc Biol. 2005 Mar;77(3):337-43. doi: 10.1189/jlb.0804441. Epub 2004 Dec 15. J Leukoc Biol. 2005. PMID: 15601667 - OS9 interacts with DC-STAMP and modulates its intracellular localization in response to TLR ligation.
Jansen BJ, Eleveld-Trancikova D, Sanecka A, van Hout-Kuijer M, Hendriks IA, Looman MG, Leusen JH, Adema GJ. Jansen BJ, et al. Mol Immunol. 2009 Feb;46(4):505-15. doi: 10.1016/j.molimm.2008.06.032. Epub 2008 Oct 25. Mol Immunol. 2009. PMID: 18952287 - Identification of a novel, dendritic cell-associated molecule, dectin-1, by subtractive cDNA cloning.
Ariizumi K, Shen GL, Shikano S, Xu S, Ritter R 3rd, Kumamoto T, Edelbaum D, Morita A, Bergstresser PR, Takashima A. Ariizumi K, et al. J Biol Chem. 2000 Jun 30;275(26):20157-67. doi: 10.1074/jbc.M909512199. J Biol Chem. 2000. PMID: 10779524 - The dendritic cell-specific transmembrane protein DC-STAMP is essential for osteoclast fusion and osteoclast bone-resorbing activity.
Miyamoto T. Miyamoto T. Mod Rheumatol. 2006;16(6):341-2. doi: 10.1007/s10165-006-0524-0. Epub 2006 Dec 20. Mod Rheumatol. 2006. PMID: 17164993 Review. - DC-STAMP, the key fusion-mediating molecule in osteoclastogenesis.
Zhang C, Dou CE, Xu J, Dong S. Zhang C, et al. J Cell Physiol. 2014 Oct;229(10):1330-5. doi: 10.1002/jcp.24553. J Cell Physiol. 2014. PMID: 24420845 Review.
Cited by
- Beyond resorption: osteoclasts as drivers of bone formation.
Xiang Q, Li L, Ji W, Gawlitta D, Walboomers XF, van den Beucken JJJP. Xiang Q, et al. Cell Regen. 2024 Oct 11;13(1):22. doi: 10.1186/s13619-024-00205-x. Cell Regen. 2024. PMID: 39392536 Free PMC article. Review. - Macrophage fusion: the making of osteoclasts and giant cells.
Vignery A. Vignery A. J Exp Med. 2005 Aug 1;202(3):337-40. doi: 10.1084/jem.20051123. J Exp Med. 2005. PMID: 16061722 Free PMC article. Review. - DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells.
Yagi M, Miyamoto T, Sawatani Y, Iwamoto K, Hosogane N, Fujita N, Morita K, Ninomiya K, Suzuki T, Miyamoto K, Oike Y, Takeya M, Toyama Y, Suda T. Yagi M, et al. J Exp Med. 2005 Aug 1;202(3):345-51. doi: 10.1084/jem.20050645. J Exp Med. 2005. PMID: 16061724 Free PMC article. - Genome-wide association identifies three new susceptibility loci for Paget's disease of bone.
Albagha OM, Wani SE, Visconti MR, Alonso N, Goodman K, Brandi ML, Cundy T, Chung PY, Dargie R, Devogelaer JP, Falchetti A, Fraser WD, Gennari L, Gianfrancesco F, Hooper MJ, Van Hul W, Isaia G, Nicholson GC, Nuti R, Papapoulos S, Montes Jdel P, Ratajczak T, Rea SL, Rendina D, Gonzalez-Sarmiento R, Di Stefano M, Ward LC, Walsh JP, Ralston SH; Genetic Determinants of Paget's Disease (GDPD) Consortium. Albagha OM, et al. Nat Genet. 2011 May 29;43(7):685-9. doi: 10.1038/ng.845. Nat Genet. 2011. PMID: 21623375 - Identification of differentially expressed genes in papillary thyroid cancers.
Lee KY, Huang SM, Li S, Kim JM. Lee KY, et al. Yonsei Med J. 2009 Feb 28;50(1):60-7. doi: 10.3349/ymj.2009.50.1.60. Epub 2009 Feb 24. Yonsei Med J. 2009. PMID: 19259350 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases