A new twist on RNA helicases: DExH/D box proteins as RNPases - PubMed (original) (raw)
Review
doi: 10.1038/84091.
Affiliations
- PMID: 11175897
- DOI: 10.1038/84091
Review
A new twist on RNA helicases: DExH/D box proteins as RNPases
B Schwer. Nat Struct Biol. 2001 Feb.
Abstract
DExH/D box proteins are required for the major transactions of RNA, including mRNA synthesis, pre-mRNA splicing, ribosome biogenesis, translation and RNA decay. In the popular imagination, DExH/D box proteins have become synonymous with 'RNA helicases', which are enzymes that unwind duplex RNAs in concert with the hydrolysis of nucleoside triphosphates (NTPs). But all DExH/D box proteins may not be RNA helicases and the energy of NTP hydrolysis by DExH/D box proteins may be harnessed for other purposes. Cellular RNAs are associated with proteins, often in large ribonucleoprotein (RNP) complexes. This review focuses on recent progress suggesting a role for DExH/D box proteins as 'RNPases' that use chemical energy to remodel the interactions of RNA and proteins.
Similar articles
- Structural aspects of RNA helicases in eukaryotic mRNA decay.
Ling SH, Cheng Z, Song H. Ling SH, et al. Biosci Rep. 2009 Jul 13;29(5):339-49. doi: 10.1042/BSR20090034. Biosci Rep. 2009. PMID: 19589129 Review. - Active disruption of an RNA-protein interaction by a DExH/D RNA helicase.
Jankowsky E, Gross CH, Shuman S, Pyle AM. Jankowsky E, et al. Science. 2001 Jan 5;291(5501):121-5. doi: 10.1126/science.291.5501.121. Science. 2001. PMID: 11141562 - Are DEAD-box proteins becoming respectable helicases?
Linder P, Daugeron MC. Linder P, et al. Nat Struct Biol. 2000 Feb;7(2):97-9. doi: 10.1038/72464. Nat Struct Biol. 2000. PMID: 10655606 - Remodeling of ribonucleoprotein complexes with DExH/D RNA helicases.
Jankowsky E, Bowers H. Jankowsky E, et al. Nucleic Acids Res. 2006;34(15):4181-8. doi: 10.1093/nar/gkl410. Epub 2006 Aug 25. Nucleic Acids Res. 2006. PMID: 16935886 Free PMC article. Review. - Protein displacement by DExH/D "RNA helicases" without duplex unwinding.
Fairman ME, Maroney PA, Wang W, Bowers HA, Gollnick P, Nilsen TW, Jankowsky E. Fairman ME, et al. Science. 2004 Apr 30;304(5671):730-4. doi: 10.1126/science.1095596. Science. 2004. PMID: 15118161
Cited by
- The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex.
Hug N, Cáceres JF. Hug N, et al. Cell Rep. 2014 Sep 25;8(6):1845-1856. doi: 10.1016/j.celrep.2014.08.020. Epub 2014 Sep 15. Cell Rep. 2014. PMID: 25220460 Free PMC article. - Structural analysis of the spliceosomal RNA helicase Prp28 from the thermophilic eukaryote Chaetomium thermophilum.
Tauchert MJ, Ficner R. Tauchert MJ, et al. Acta Crystallogr F Struct Biol Commun. 2016 May;72(Pt 5):409-16. doi: 10.1107/S2053230X16006038. Epub 2016 Apr 22. Acta Crystallogr F Struct Biol Commun. 2016. PMID: 27139834 Free PMC article. - Role of transcription in plasmid maintenance in the hpr1Delta mutant of Saccharomyces cerevisiae.
Merker RJ, Klein HL. Merker RJ, et al. Mol Cell Biol. 2002 Dec;22(24):8763-73. doi: 10.1128/MCB.22.24.8763-8773.2002. Mol Cell Biol. 2002. PMID: 12446793 Free PMC article. - ATP requirement for Prp5p function is determined by Cus2p and the structure of U2 small nuclear RNA.
Perriman R, Barta I, Voeltz GK, Abelson J, Ares M Jr. Perriman R, et al. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13857-62. doi: 10.1073/pnas.2036312100. Epub 2003 Nov 10. Proc Natl Acad Sci U S A. 2003. PMID: 14610285 Free PMC article. - UAP56 is an important regulator of protein synthesis and growth in cardiomyocytes.
Sahni A, Wang N, Alexis JD. Sahni A, et al. Biochem Biophys Res Commun. 2010 Feb 26;393(1):106-10. doi: 10.1016/j.bbrc.2010.01.093. Epub 2010 Jan 29. Biochem Biophys Res Commun. 2010. PMID: 20116367 Free PMC article.