Genomewide genetic linkage analysis confirms the presence of susceptibility loci for schizophrenia, on chromosomes 1q32.2, 5q33.2, and 8p21-22 and provides support for linkage to schizophrenia, on chromosomes 11q23.3-24 and 20q12.1-11.23 - PubMed (original) (raw)

The Epsin 4 gene on chromosome 5q, which encodes the clathrin-associated protein enthoprotin, is involved in the genetic susceptibility to schizophrenia.

Pimm J, McQuillin A, Thirumalai S, Lawrence J, Quested D, Bass N, Lamb G, Moorey H, Datta SR, Kalsi G, Badacsonyi A, Kelly K, Morgan J, Punukollu B, Curtis D, Gurling H. Pimm J, et al. Am J Hum Genet. 2005 May;76(5):902-7. doi: 10.1086/430095. Epub 2005 Mar 25. Am J Hum Genet. 2005. PMID: 15793701 Free PMC article.

A genetic association study of chromosome 11q22-24 in two different samples implicates the FXYD6 gene, encoding phosphohippolin, in susceptibility to schizophrenia.

Choudhury K, McQuillin A, Puri V, Pimm J, Datta S, Thirumalai S, Krasucki R, Lawrence J, Bass NJ, Quested D, Crombie C, Fraser G, Walker N, Nadeem H, Johnson S, Curtis D, St Clair D, Gurling HM. Choudhury K, et al. Am J Hum Genet. 2007 Apr;80(4):664-72. doi: 10.1086/513475. Epub 2007 Mar 1. Am J Hum Genet. 2007. PMID: 17357072 Free PMC article.

Genome wide significant linkage in schizophrenia conditioning on occurrence of depressive episodes.

Hamshere ML, Williams NM, Norton N, Williams H, Cardno AG, Zammit S, Jones LA, Murphy KC, Sanders RD, McCarthy G, Gray MY, Jones G, Holmans P, O'Donovan MC, Owen MJ, Craddock N. Hamshere ML, et al. J Med Genet. 2006 Jul;43(7):563-7. doi: 10.1136/jmg.2005.035345. Epub 2005 Oct 14. J Med Genet. 2006. PMID: 16227524 Free PMC article.

Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia.

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