The protein-protein interaction map of Helicobacter pylori - PubMed (original) (raw)
. 2001 Jan 11;409(6817):211-5.
doi: 10.1038/35051615.
L Selig, H De Reuse, V Battaglia, C Reverdy, S Simon, G Lenzen, F Petel, J Wojcik, V Schächter, Y Chemama, A Labigne, P Legrain
Affiliations
- PMID: 11196647
- DOI: 10.1038/35051615
The protein-protein interaction map of Helicobacter pylori
J C Rain et al. Nature. 2001.
Erratum in
- Nature 2001 Feb 1;409(6820):553
- Nature 2001 Feb 8;409(6821):743
Abstract
With the availability of complete DNA sequences for many prokaryotic and eukaryotic genomes, and soon for the human genome itself, it is important to develop reliable proteome-wide approaches for a better understanding of protein function. As elementary constituents of cellular protein complexes and pathways, protein-protein interactions are key determinants of protein function. Here we have built a large-scale protein-protein interaction map of the human gastric pathogen Helicobacter pylori. We have used a high-throughput strategy of the yeast two-hybrid assay to screen 261 H. pylori proteins against a highly complex library of genome-encoded polypeptides. Over 1,200 interactions were identified between H. pylori proteins, connecting 46.6% of the proteome. The determination of a reliability score for every single protein-protein interaction and the identification of the actual interacting domains permitted the assignment of unannotated proteins to biological pathways.
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