Cocaine catalytic antibodies: the primary importance of linker effects - PubMed (original) (raw)
Cocaine catalytic antibodies: the primary importance of linker effects
M Matsushita et al. Bioorg Med Chem Lett. 2001.
Abstract
Current treatments for cocaine addiction are not effective. The development of a catalytic monoclonal antibody (mAb) provides a strategy for not only binding, but also degrading cocaine, which offers a broad-based therapy. Hapten design is the central element for programming antibody catalysis. The characteristics of the linker used in classic transition-state analogue phosphonate haptens were shown to be important for obtaining mAbs that hydrolyze the benzoate ester of cocaine.