A genomic perspective on membrane compartment organization - PubMed (original) (raw)
. 2001 Feb 15;409(6822):839-41.
doi: 10.1038/35057024.
Affiliations
- PMID: 11237004
- DOI: 10.1038/35057024
A genomic perspective on membrane compartment organization
J B Bock et al. Nature. 2001.
Abstract
Now that whole genome sequences are available for many eukaryotic organisms from yeast to man, we can form broad hypotheses on the basis of the relative expansion of protein families. To investigate the molecular mechanisms responsible for the organization of membrane compartments, we identified members of the SNARE, coat complex, Rab and Sec1 protein families in four eukaryotic genomes. Of these families only the Rab family expanded from the unicellular yeast to the multicellular fly and worm. All families were expanded in humans, where we find 35 SNAREs, 60 Rabs and 53 coat complex subunits. In addition, we were able to resolve the SNARE class of proteins into four distinct subfamilies.
Comment in
- Arabidopsis could shed light on human genome.
Sanderfoot AA, Raikhel NV. Sanderfoot AA, et al. Nature. 2001 Mar 15;410(6826):299. doi: 10.1038/35066726. Nature. 2001. PMID: 11268174 No abstract available.
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