The amygdala is essential for the development of neuronal plasticity in the medial geniculate nucleus during auditory fear conditioning in rats - PubMed (original) (raw)
The amygdala is essential for the development of neuronal plasticity in the medial geniculate nucleus during auditory fear conditioning in rats
S Maren et al. J Neurosci. 2001.
Abstract
The medial geniculate nucleus of the thalamus (MGN) and the basolateral complex of the amygdala (BLA) are critical components of the neural circuit that mediates auditory fear conditioning. Several studies indicate that neurons in both the MGN and BLA exhibit associative plasticity of spike firing during auditory fear conditioning. In the present study, we examined whether the development of plasticity in the MGN requires the BLA. Single units were recorded from chronic multichannel electrodes implanted in the medial division of the MGN of conscious and freely moving rats. Rats received auditory fear conditioning trials, which consisted of a white-noise conditional stimulus (CS) and a co-terminating footshock unconditional stimulus (US). Unpaired (sensitization) controls received the same number of trials as paired animals, but the CS and US were explicitly unpaired. Before fear conditioning, rats received either an intra-amygdala infusion of muscimol, a GABA(A) receptor agonist, to inactivate BLA neurons or an infusion of the saline vehicle. Auditory fear conditioning produced a substantial increase in both CS-elicited spike firing in the MGN and conditional freezing behavior in vehicle-treated rats receiving paired training. Muscimol inactivation of the BLA severely attenuated the development of both conditioning-related increases in CS-elicited spike firing in the MGN and conditional freezing to the auditory CS. Unpaired training did not yield increases in either CS-elicited spike firing or freezing to the tone CS. These results reveal that the BLA is essential to the development of plasticity in the auditory thalamus during fear conditioning.
Similar articles
- Auditory fear conditioning increases CS-elicited spike firing in lateral amygdala neurons even after extensive overtraining.
Maren S. Maren S. Eur J Neurosci. 2000 Nov;12(11):4047-54. doi: 10.1046/j.1460-9568.2000.00281.x. Eur J Neurosci. 2000. PMID: 11069601 - Auditory-evoked spike firing in the lateral amygdala and Pavlovian fear conditioning: mnemonic code or fear bias?
Goosens KA, Hobin JA, Maren S. Goosens KA, et al. Neuron. 2003 Dec 4;40(5):1013-22. doi: 10.1016/s0896-6273(03)00728-1. Neuron. 2003. PMID: 14659099 - Fear Learning: An Evolving Picture for Plasticity at Synaptic Afferents to the Amygdala.
Palchaudhuri S, Osypenko D, Schneggenburger R. Palchaudhuri S, et al. Neuroscientist. 2024 Feb;30(1):87-104. doi: 10.1177/10738584221108083. Epub 2022 Jul 13. Neuroscientist. 2024. PMID: 35822657 Review. - Synaptic encoding of fear memories in the amygdala.
Ressler RL, Maren S. Ressler RL, et al. Curr Opin Neurobiol. 2019 Feb;54:54-59. doi: 10.1016/j.conb.2018.08.012. Epub 2018 Sep 11. Curr Opin Neurobiol. 2019. PMID: 30216780 Free PMC article. Review.
Cited by
- Involvement of the GABAergic system in PTSD and its therapeutic significance.
Huang J, Xu F, Yang L, Tuolihong L, Wang X, Du Z, Zhang Y, Yin X, Li Y, Lu K, Wang W. Huang J, et al. Front Mol Neurosci. 2023 Feb 1;16:1052288. doi: 10.3389/fnmol.2023.1052288. eCollection 2023. Front Mol Neurosci. 2023. PMID: 36818657 Free PMC article. Review. - Sounding the Alarm: Sex Differences in Rat Ultrasonic Vocalizations during Pavlovian Fear Conditioning and Extinction.
Laine MA, Mitchell JR, Rhyner J, Clark R, Kannan A, Keith J, Pikus M, Bergeron E, Ravaglia I, Ulgenturk E, Shinde A, Shansky RM. Laine MA, et al. eNeuro. 2022 Dec 23;9(6):ENEURO.0382-22.2022. doi: 10.1523/ENEURO.0382-22.2022. Print 2022 Nov-Dec. eNeuro. 2022. PMID: 36443006 Free PMC article. - Dissociated Role of Thalamic and Cortical Input to the Lateral Amygdala for Consolidation of Long-Term Fear Memory.
Lee Y, Oh JP, Han JH. Lee Y, et al. J Neurosci. 2021 Nov 17;41(46):9561-9570. doi: 10.1523/JNEUROSCI.1167-21.2021. Epub 2021 Oct 19. J Neurosci. 2021. PMID: 34667069 Free PMC article. - Single cell plasticity and population coding stability in auditory thalamus upon associative learning.
Taylor JA, Hasegawa M, Benoit CM, Freire JA, Theodore M, Ganea DA, Innocenti SM, Lu T, Gründemann J. Taylor JA, et al. Nat Commun. 2021 Apr 26;12(1):2438. doi: 10.1038/s41467-021-22421-8. Nat Commun. 2021. PMID: 33903596 Free PMC article. - Stress-Induced Morphological, Cellular and Molecular Changes in the Brain-Lessons Learned from the Chronic Mild Stress Model of Depression.
Khan AR, Geiger L, Wiborg O, Czéh B. Khan AR, et al. Cells. 2020 Apr 21;9(4):1026. doi: 10.3390/cells9041026. Cells. 2020. PMID: 32326205 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources