The many substrates and functions of ATM - PubMed (original) (raw)

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The many substrates and functions of ATM

M B Kastan et al. Nat Rev Mol Cell Biol. 2000 Dec.

Abstract

As its name suggests, the ATM--'ataxia-telangiectasia, mutated'--gene is responsible for the rare disorder ataxia-telangiectasia. Patients show various abnormalities, mainly in their responses to DNA damage, but also in other cellular processes. Although it is hard to understand how a single gene product is involved in so many physiological processes, a clear picture is starting to emerge.

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