Retrograde amnesia after hippocampal damage: recent vs. remote memories in two tasks - PubMed (original) (raw)

Review

doi: 10.1002/1098-1063(2001)11:1<27::AID-HIPO1017>3.0.CO;2-4.

M P Weisend, D Mumby, R S Astur, F M Hanlon, A Koerner, M J Thomas, Y Wu, S N Moses, C Cole, D A Hamilton, J M Hoesing

Affiliations

Review

Retrograde amnesia after hippocampal damage: recent vs. remote memories in two tasks

R J Sutherland et al. Hippocampus. 2001.

Abstract

We review evidence from experiments conducted in our laboratory on retrograde amnesia in rats with damage to the hippocampal formation. In a new experiment reported here, we show that N-methyl-D-aspartate (NMDA)-induced hippocampal damage produced retrograde amnesia for both hidden platform and two-choice visible platform discriminations in the Morris water task. For both problems there was a significant trend for longer training-surgery intervals to be associated with worse retention performance. Little support is offered by our work for the concept that there is a process involving hippocampal-dependent consolidation of memories in extrahippocampal permanent storage sites. Long-term memory consolidation may take place within the hippocampus. The hippocampus may be involved permanently in storage and/or retrieval of a variety of relational and nonrelational memories if it was intact at the time of learning, even involving information which is definitely not affected in anterograde amnesia after hippocampal damage.

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