Wnt signalling: a theme with nuclear variations - PubMed (original) (raw)
Review
Wnt signalling: a theme with nuclear variations
C Sharpe et al. Bioessays. 2001 Apr.
Abstract
Wnt proteins are involved in a large number of events during development and disease. The crucial element in the transduction of the signal elicited by Wnt is the state and activity of beta-catenin. There are two pools of beta-catenin, one associated with cadherins at the cell surface and a soluble one in the cytolasm, whose state and concentration are critical for Wnt signalling. In the absence of Wnt, the cytoplasmic pool is low due to targetted degradation of beta-catenin. Upon Wnt signalling, beta-catenin is stabilized. As a consequence, it can access the nucleus where it interacts with members of the Tcf family of transcription factors to modulate the expression of defined targets. Recent reports indicate that, in addition to Tcfs, beta-catenin can interact with other nuclear proteins raising the possibility that Wnt signalling has a wider modulatory effect on transcription than is mediated by its interactions with Tcfs. BioEssays 23:311-318, 2001.
Copyright 2001 John Wiley & Sons, Inc.
Similar articles
- WNT-1 and HGF regulate GSK3 beta activity and beta-catenin signaling in mammary epithelial cells.
Papkoff J, Aikawa M. Papkoff J, et al. Biochem Biophys Res Commun. 1998 Jun 29;247(3):851-8. doi: 10.1006/bbrc.1998.8888. Biochem Biophys Res Commun. 1998. PMID: 9647782 - Constitutive activation of Wnt/beta-catenin signaling pathway in migration-active melanoma cells: role of LEF-1 in melanoma with increased metastatic potential.
Murakami T, Toda S, Fujimoto M, Ohtsuki M, Byers HR, Etoh T, Nakagawa H. Murakami T, et al. Biochem Biophys Res Commun. 2001 Oct 19;288(1):8-15. doi: 10.1006/bbrc.2001.5719. Biochem Biophys Res Commun. 2001. PMID: 11594745 - Beta-catenin can act as a nuclear import receptor for its partner transcription factor, lymphocyte enhancer factor-1 (lef-1).
Asally M, Yoneda Y. Asally M, et al. Exp Cell Res. 2005 Aug 15;308(2):357-63. doi: 10.1016/j.yexcr.2005.05.011. Exp Cell Res. 2005. PMID: 15936755 - The promise and perils of Wnt signaling through beta-catenin.
Moon RT, Bowerman B, Boutros M, Perrimon N. Moon RT, et al. Science. 2002 May 31;296(5573):1644-6. doi: 10.1126/science.1071549. Science. 2002. PMID: 12040179 Review. - [Regulation of transcription in the Wnt signaling pathway].
Yamashina K, Kikuchi A. Yamashina K, et al. Tanpakushitsu Kakusan Koso. 2004 Aug;49(10):1421-7. Tanpakushitsu Kakusan Koso. 2004. PMID: 15346893 Review. Japanese. No abstract available.
Cited by
- Receptor and secreted targets of Wnt-1/beta-catenin signalling in mouse mammary epithelial cells.
Kenny PA, Enver T, Ashworth A. Kenny PA, et al. BMC Cancer. 2005 Jan 10;5:3. doi: 10.1186/1471-2407-5-3. BMC Cancer. 2005. PMID: 15642117 Free PMC article. - Genetics of Combined Pituitary Hormone Deficiency: Roadmap into the Genome Era.
Fang Q, George AS, Brinkmeier ML, Mortensen AH, Gergics P, Cheung LY, Daly AZ, Ajmal A, Pérez Millán MI, Ozel AB, Kitzman JO, Mills RE, Li JZ, Camper SA. Fang Q, et al. Endocr Rev. 2016 Dec;37(6):636-675. doi: 10.1210/er.2016-1101. Epub 2016 Nov 9. Endocr Rev. 2016. PMID: 27828722 Free PMC article. Review. - Beta-catenin promotes survival of renal epithelial cells by inhibiting Bax.
Wang Z, Havasi A, Gall JM, Mao H, Schwartz JH, Borkan SC. Wang Z, et al. J Am Soc Nephrol. 2009 Sep;20(9):1919-28. doi: 10.1681/ASN.2009030253. Epub 2009 Aug 20. J Am Soc Nephrol. 2009. PMID: 19696224 Free PMC article. - Genetic Redundancies Enhance Information Transfer in Noisy Regulatory Circuits.
Rodrigo G, Poyatos JF. Rodrigo G, et al. PLoS Comput Biol. 2016 Oct 14;12(10):e1005156. doi: 10.1371/journal.pcbi.1005156. eCollection 2016 Oct. PLoS Comput Biol. 2016. PMID: 27741249 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous