The molecular machinery for lysosome biogenesis - PubMed (original) (raw)
Review
The molecular machinery for lysosome biogenesis
C Mullins et al. Bioessays. 2001 Apr.
Abstract
The lysosome serves as a site for delivery of materials targeted for removal from the eukaryotic cell. The mechanisms underlying the biogenesis of this organelle are currently the subject of renewed interest due to advances in our understanding of the protein sorting machinery. Genetic model systems such as yeast and Drosophila have been instrumental in identifying both protein and lipid components of this machinery. Importantly, many of these components, as well as the processes in which they are involved, are proving conserved in mammals. Other recently identified components, however, appear to be unique to higher eukaryotes. BioEssays 23:333-343, 2001. Published 2001 John Wiley & Sons, Inc.
Similar articles
- Novel pathways, membrane coats and PI kinase regulation in yeast lysosomal trafficking.
Burd CG, Babst M, Emr SD. Burd CG, et al. Semin Cell Dev Biol. 1998 Oct;9(5):527-33. doi: 10.1006/scdb.1998.0255. Semin Cell Dev Biol. 1998. PMID: 9835640 Review. - Domains of the TGN: coats, tethers and G proteins.
Gleeson PA, Lock JG, Luke MR, Stow JL. Gleeson PA, et al. Traffic. 2004 May;5(5):315-26. doi: 10.1111/j.1398-9219.2004.00182.x. Traffic. 2004. PMID: 15086781 Review. - GGAing ubiquitin to the endosome.
Babst M. Babst M. Nat Cell Biol. 2004 Mar;6(3):175-7. doi: 10.1038/ncb0304-175. Nat Cell Biol. 2004. PMID: 15039783 No abstract available. - Formation of AP-3 transport intermediates requires Vps41 function.
Rehling P, Darsow T, Katzmann DJ, Emr SD. Rehling P, et al. Nat Cell Biol. 1999 Oct;1(6):346-53. doi: 10.1038/14037. Nat Cell Biol. 1999. PMID: 10559961 - Dominant-negative mutant of BIG2, an ARF-guanine nucleotide exchange factor, specifically affects membrane trafficking from the trans-Golgi network through inhibiting membrane association of AP-1 and GGA coat proteins.
Shinotsuka C, Waguri S, Wakasugi M, Uchiyama Y, Nakayama K. Shinotsuka C, et al. Biochem Biophys Res Commun. 2002 Jun 7;294(2):254-60. doi: 10.1016/S0006-291X(02)00456-4. Biochem Biophys Res Commun. 2002. PMID: 12051703
Cited by
- The ubiquitin-proteasome system and the autophagic-lysosomal system in Alzheimer disease.
Ihara Y, Morishima-Kawashima M, Nixon R. Ihara Y, et al. Cold Spring Harb Perspect Med. 2012 Aug 1;2(8):a006361. doi: 10.1101/cshperspect.a006361. Cold Spring Harb Perspect Med. 2012. PMID: 22908190 Free PMC article. - Numerous transcriptional alterations in liver persist after short-term enzyme-replacement therapy in a murine model of mucopolysaccharidosis type VII.
Woloszynek JC, Roberts M, Coleman T, Vogler C, Sly W, Semenkovich CF, Sands MS. Woloszynek JC, et al. Biochem J. 2004 Apr 15;379(Pt 2):461-9. doi: 10.1042/BJ20031048. Biochem J. 2004. PMID: 14705966 Free PMC article. - glo-3, a novel Caenorhabditis elegans gene, is required for lysosome-related organelle biogenesis.
Rabbitts BM, Ciotti MK, Miller NE, Kramer M, Lawrenson AL, Levitte S, Kremer S, Kwan E, Weis AM, Hermann GJ. Rabbitts BM, et al. Genetics. 2008 Oct;180(2):857-71. doi: 10.1534/genetics.108.093534. Epub 2008 Sep 9. Genetics. 2008. PMID: 18780725 Free PMC article. - Functional genomics of monensin sensitivity in yeast: implications for post-Golgi traffic and vacuolar H+-ATPase function.
Gustavsson M, Barmark G, Larsson J, Murén E, Ronne H. Gustavsson M, et al. Mol Genet Genomics. 2008 Sep;280(3):233-48. doi: 10.1007/s00438-008-0359-9. Epub 2008 Jul 9. Mol Genet Genomics. 2008. PMID: 18612650 - Inhibition of insulin-like growth factor II (IGF-II)-dependent cell growth by multidentate pentamannosyl 6-phosphate-based ligands targeting the mannose 6-phosphate/IGF-II receptor.
Zavorka ME, Connelly CM, Grosely R, MacDonald RG. Zavorka ME, et al. Oncotarget. 2016 Sep 20;7(38):62386-62410. doi: 10.18632/oncotarget.11493. Oncotarget. 2016. PMID: 27694692 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases