A fresh look at tumor immunosurveillance and immunotherapy - PubMed (original) (raw)
Review
doi: 10.1038/86297.
Affiliations
- PMID: 11276199
- DOI: 10.1038/86297
Review
A fresh look at tumor immunosurveillance and immunotherapy
M J Smyth et al. Nat Immunol. 2001 Apr.
Abstract
Despite major advances in our understanding of adaptive immunity and dendritic cells, consistent and durable responses to cancer vaccines remain elusive and active immunotherapy is still not an established treatment modality. The key to developing an effective anti-tumor response is understanding why, initially, the immune system is unable to detect transformed cells and is subsequently tolerant of tumor growth and metastasis. Ineffective antigen presentation limits the adaptive immune response; however, we are now learning that the host's innate immune system may first fail to recognize the tumor as posing a danger. Recent descriptions of stress-induced ligands on tumor cells recognized by innate effector cells, new subsets of T cells that regulate tumor tolerance and the development of spontaneous tumors in mice that lack immune effector molecules, beckon a reflection on our current perspectives on the interaction of transformed cells with the immune system and offer new hope of stimulating therapeutic immunity to cancer.
Similar articles
- Tumor immunity and immunotherapy.
Boura P, Kountouras J, Lygidakis NJ. Boura P, et al. Hepatogastroenterology. 2001 Jul-Aug;48(40):1040-4. Hepatogastroenterology. 2001. PMID: 11490795 Review. - Immunology and breast cancer: therapeutic cancer vaccines.
Curigliano G, Rescigno M, Goldhirsch A. Curigliano G, et al. Breast. 2007 Dec;16 Suppl 2:S20-6. doi: 10.1016/j.breast.2007.07.004. Epub 2007 Aug 13. Breast. 2007. PMID: 17706425 Review. - Tumor-host immune interactions and dendritic cell dysfunction.
Yang L, Carbone DP. Yang L, et al. Adv Cancer Res. 2004;92:13-27. doi: 10.1016/S0065-230X(04)92002-7. Adv Cancer Res. 2004. PMID: 15530555 Review. - [Cytotoxic T lymphocytes: role in immunosurveillance and in immunotherapy].
Benchetrit F, Gazagne A, Adotevi O, Haicheur N, Godard B, Badoual C, Fridman WH, Tartour E. Benchetrit F, et al. Bull Cancer. 2003 Aug-Sep;90(8-9):677-85. Bull Cancer. 2003. PMID: 14609756 Review. French. - Immune responses to human tumors: development of tumor vaccines.
Platsoucas CD, Fincke JE, Pappas J, Jung WJ, Heckel M, Schwarting R, Magira E, Monos D, Freedman RS. Platsoucas CD, et al. Anticancer Res. 2003 May-Jun;23(3A):1969-96. Anticancer Res. 2003. PMID: 12894571 Review.
Cited by
- A battle between two biological singularities: Immune response vs. cancer.
Katakai T, Okazaki T. Katakai T, et al. Biophys Physicobiol. 2024 Feb 9;21(Supplemental):e211006. doi: 10.2142/biophysico.bppb-v21.s006. eCollection 2024. Biophys Physicobiol. 2024. PMID: 39175864 Free PMC article. Review. - Metal-based nanoparticle in cancer treatment: lessons learned and challenges.
Hheidari A, Mohammadi J, Ghodousi M, Mahmoodi M, Ebrahimi S, Pishbin E, Rahdar A. Hheidari A, et al. Front Bioeng Biotechnol. 2024 Jul 11;12:1436297. doi: 10.3389/fbioe.2024.1436297. eCollection 2024. Front Bioeng Biotechnol. 2024. PMID: 39055339 Free PMC article. Review. - Recurrence-free survival after curative resection of non-small cell lung cancer between inhalational gas anesthesia and propofol-based total intravenous anesthesia: a multicenter, randomized, clinical trial (GAS TIVA trial): protocol description.
Kim J, Yoon S, Song IK, Lee K, Hwang W, Kim H, Lee DK, Lim HK, Kim SH, Lee JW, Hong B, Blank RS, Pedoto A, Popescu W, Theresa G, Martin AK, Patteril M, Pathanasethpong A, Thongsuk Y, Pisitpitayasaree T, Huang A, Yu H, Kapoor PM, Kim K, Chi SA, Ahn HJ. Kim J, et al. Perioper Med (Lond). 2024 Jul 23;13(1):79. doi: 10.1186/s13741-024-00436-1. Perioper Med (Lond). 2024. PMID: 39039548 Free PMC article. - Anesthesia and cancer recurrence: a narrative review.
Ahn HJ. Ahn HJ. Anesth Pain Med (Seoul). 2024 Apr;19(2):94-108. doi: 10.17085/apm.24041. Epub 2024 Apr 30. Anesth Pain Med (Seoul). 2024. PMID: 38725164 Free PMC article. Review. - Applications of Intravital Imaging in Cancer Immunotherapy.
Deng D, Hao T, Lu L, Yang M, Zeng Z, Lovell JF, Liu Y, Jin H. Deng D, et al. Bioengineering (Basel). 2024 Mar 8;11(3):264. doi: 10.3390/bioengineering11030264. Bioengineering (Basel). 2024. PMID: 38534538 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases