Addiction and the brain: the role of neurotransmitters in the cause and treatment of drug dependence - PubMed (original) (raw)
Review
. 2001 Mar 20;164(6):817-21.
Affiliations
- PMID: 11276551
- PMCID: PMC80880
Review
Addiction and the brain: the role of neurotransmitters in the cause and treatment of drug dependence
D M Tomkins et al. CMAJ. 2001.
Abstract
Recent scientific advances have led to a greater understanding of the neurobiological processes that underlie drug abuse and addiction. These suggest that multiple neurotransmitter systems may play a key role in the development and expression of drug dependence. These advances in our knowledge promise not only to help us identify the underlying cause of drug abuse and dependence, but also to aid the development of effective treatment strategies.
Figures
Fig. 1: Schematic diagram of the human brain that highlights some of the main brain areas and neurotransmitter pathways implicated in reward processes. Photo by: Lianne Friesen
Fig. 2: Schematic diagram that represents the dopamine pathway projecting from the ventral tegmental area (VTA) to the nucleus accumbens (NAcc), indicating how substances of abuse can alter the activity of this pathway to produce their rewarding effects. Photo by: Lianne Friesen
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