Rac1 activity is required for the activation of hypoxia-inducible factor 1 - PubMed (original) (raw)
. 2001 Jun 15;276(24):21166-72.
doi: 10.1074/jbc.M100677200. Epub 2001 Mar 30.
Affiliations
- PMID: 11283021
- DOI: 10.1074/jbc.M100677200
Free article
Rac1 activity is required for the activation of hypoxia-inducible factor 1
K Hirota et al. J Biol Chem. 2001.
Free article
Abstract
Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that mediates cellular and systemic homeostatic responses (including erythropoiesis, angiogenesis, and glycolysis) to reduced O(2) availability in mammals. Hypoxia induces both the protein expression and transcriptional activity of the HIF-1alpha subunit. However, the molecular mechanisms of sensing and signal transduction by which changes in O(2) concentration result in changes in HIF-1 activity are poorly understood. We report here that the small GTPase Rac1 is activated in response to hypoxia and is required for the induction of HIF-1alpha protein expression and transcriptional activity in hypoxic cells.
Similar articles
- Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.
Hudson CC, Liu M, Chiang GG, Otterness DM, Loomis DC, Kaper F, Giaccia AJ, Abraham RT. Hudson CC, et al. Mol Cell Biol. 2002 Oct;22(20):7004-14. doi: 10.1128/MCB.22.20.7004-7014.2002. Mol Cell Biol. 2002. PMID: 12242281 Free PMC article. - Transduction pathways involved in Hypoxia-Inducible Factor-1 phosphorylation and activation.
Minet E, Michel G, Mottet D, Raes M, Michiels C. Minet E, et al. Free Radic Biol Med. 2001 Oct 1;31(7):847-55. doi: 10.1016/s0891-5849(01)00657-8. Free Radic Biol Med. 2001. PMID: 11585703 Review. - Hypoxia-inducible factor 1: master regulator of O2 homeostasis.
Semenza GL. Semenza GL. Curr Opin Genet Dev. 1998 Oct;8(5):588-94. doi: 10.1016/s0959-437x(98)80016-6. Curr Opin Genet Dev. 1998. PMID: 9794818 Review.
Cited by
- PICK1 modulates glycolysis and angiogenesis of hypoxic endothelial cells by regulating iron homeostasis.
Cao Y, Wang H, Hu S, Xu Q, Ma J, Wang H, Xiong X, Wang W, Wang L. Cao Y, et al. Mol Cell Biochem. 2024 May;479(5):1297-1312. doi: 10.1007/s11010-023-04795-z. Epub 2023 Jun 27. Mol Cell Biochem. 2024. PMID: 37368155 - Pangenome obtained by long-read sequencing of 11 genomes reveal hidden functional structural variants in pigs.
Jiang YF, Wang S, Wang CL, Xu RH, Wang WW, Jiang Y, Wang MS, Jiang L, Dai LH, Wang JR, Chu XH, Zeng YQ, Fang LZ, Wu DD, Zhang Q, Ding XD. Jiang YF, et al. iScience. 2023 Feb 2;26(3):106119. doi: 10.1016/j.isci.2023.106119. eCollection 2023 Mar 17. iScience. 2023. PMID: 36852268 Free PMC article. - Clinical Significance of Combined Epithelial-Mesenchymal Transition Markers Expression and Role of Rac1 in Hepatocellular Carcinoma.
Shin SK, Ryu S, Nam S, Ha SY, Kwon OS, Kim YS, Kim SH, Kim JH. Shin SK, et al. Int J Mol Sci. 2023 Jan 16;24(2):1765. doi: 10.3390/ijms24021765. Int J Mol Sci. 2023. PMID: 36675278 Free PMC article. - Hypoxia mimetics restore bone biomineralisation in hyperglycaemic environments.
Rezaei A, Li Y, Turmaine M, Bertazzo S, Howard CA, Arnett TR, Shakib K, Jell G. Rezaei A, et al. Sci Rep. 2022 Aug 17;12(1):13944. doi: 10.1038/s41598-022-18067-1. Sci Rep. 2022. PMID: 35977987 Free PMC article. - De novo assembly of a Tibetan genome and identification of novel structural variants associated with high-altitude adaptation.
Ouzhuluobu; He Y, Lou H, Cui C, Deng L, Gao Y, Zheng W, Guo Y, Wang X, Ning Z, Li J, Li B, Bai C; Baimakangzhuo; Gonggalanzi; Dejiquzong; Bianba; Duojizhuoma; Liu S, Wu T, Xu S, Qi X, Su B. Ouzhuluobu, et al. Natl Sci Rev. 2020 Feb;7(2):391-402. doi: 10.1093/nsr/nwz160. Epub 2019 Oct 23. Natl Sci Rev. 2020. PMID: 34692055 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials