Oxidative stress increases MICA and MICB gene expression in the human colon carcinoma cell line (CaCo-2) - PubMed (original) (raw)

Oxidative stress increases MICA and MICB gene expression in the human colon carcinoma cell line (CaCo-2)

K Yamamoto et al. Biochim Biophys Acta. 2001.

Abstract

The human major histocompatibility complex class I chain-related A gene (MICA) and the MICB gene are newly identified members of the major histocompatibility complex class I chain-related gene family. We demonstrate here that oxidative stress, induced by H(2)O(2), promoted MICA (2.2-fold) and MICB (3.8-fold) gene expression using the human colon carcinoma cell line (CaCo-2) and semi-quantitative RT-PCR.

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