Steered molecular dynamics and mechanical functions of proteins - PubMed (original) (raw)
Review
Steered molecular dynamics and mechanical functions of proteins
B Isralewitz et al. Curr Opin Struct Biol. 2001 Apr.
Abstract
Atomic force microscopy of single molecules, steered molecular dynamics and the theory of stochastic processes have established a new field that investigates mechanical functions of proteins, such as ligand-receptor binding/unbinding and elasticity of muscle proteins during stretching. The combination of these methods yields information on the energy landscape that controls mechanical function and on the force-bearing components of proteins, as well as on the underlying physical mechanisms.
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