Activated caspase-3 expression in Alzheimer's and aged control brain: correlation with Alzheimer pathology - PubMed (original) (raw)
Activated caspase-3 expression in Alzheimer's and aged control brain: correlation with Alzheimer pathology
J H Su et al. Brain Res. 2001.
Abstract
Several studies have suggested that activated caspase-3 has properties of a cell death executioner protease. In this study, we examined the expression of activated caspase-3 in AD and aged control brains. Activated caspase-3 immunoreactivity was seen in neurons, astrocytes, and blood vessels, was elevated in AD, and exhibited a high degree of colocalization with neurofibrillary tangles and senile plaques. These data suggest that activated caspase-3 may be a factor in functional decline and may have an important role in neuronal cell death and plaque formation in AD brain.
Similar articles
- Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain.
Rohn TT, Rissman RA, Davis MC, Kim YE, Cotman CW, Head E. Rohn TT, et al. Neurobiol Dis. 2002 Nov;11(2):341-54. doi: 10.1006/nbdi.2002.0549. Neurobiol Dis. 2002. PMID: 12505426 - In situ immunodetection of neuronal caspase-3 activation in Alzheimer disease.
Selznick LA, Holtzman DM, Han BH, Gökden M, Srinivasan AN, Johnson EM Jr, Roth KA. Selznick LA, et al. J Neuropathol Exp Neurol. 1999 Sep;58(9):1020-6. doi: 10.1097/00005072-199909000-00012. J Neuropathol Exp Neurol. 1999. PMID: 10499444 - Brain prolyl oligopeptidase activity is associated with neuronal damage rather than beta-amyloid accumulation.
Laitinen KS, van Groen T, Tanila H, Venäläinen J, Männistö PT, Alafuzoff I. Laitinen KS, et al. Neuroreport. 2001 Oct 29;12(15):3309-12. doi: 10.1097/00001756-200110290-00032. Neuroreport. 2001. PMID: 11711876 - The role of caspase cleavage of tau in Alzheimer disease neuropathology.
Cotman CW, Poon WW, Rissman RA, Blurton-Jones M. Cotman CW, et al. J Neuropathol Exp Neurol. 2005 Feb;64(2):104-12. doi: 10.1093/jnen/64.2.104. J Neuropathol Exp Neurol. 2005. PMID: 15751224 Review. - Neuropathological changes in aging brain.
Xekardaki A, Kövari E, Gold G, Papadimitropoulou A, Giacobini E, Herrmann F, Giannakopoulos P, Bouras C. Xekardaki A, et al. Adv Exp Med Biol. 2015;821:11-7. doi: 10.1007/978-3-319-08939-3_6. Adv Exp Med Biol. 2015. PMID: 25416106 Review.
Cited by
- High-fat diet feeding causes rapid, non-apoptotic cleavage of caspase-3 in astrocytes.
Guyenet SJ, Nguyen HT, Hwang BH, Schwartz MW, Baskin DG, Thaler JP. Guyenet SJ, et al. Brain Res. 2013 May 28;1512:97-105. doi: 10.1016/j.brainres.2013.03.033. Epub 2013 Mar 30. Brain Res. 2013. PMID: 23548599 Free PMC article. - Pin1 and Alzheimer's disease.
Malter JS. Malter JS. Transl Res. 2023 Apr;254:24-33. doi: 10.1016/j.trsl.2022.09.003. Epub 2022 Sep 23. Transl Res. 2023. PMID: 36162703 Free PMC article. Review. - Fas ligand-mediated apoptosis in degenerative disorders of the brain.
Ethell DW, Buhler LA. Ethell DW, et al. J Clin Immunol. 2003 Sep;23(5):363-70. doi: 10.1023/a:1025317516396. J Clin Immunol. 2003. PMID: 14601644 Review. - A Closer Look into the Role of Protein Tau in the Identification of Promising Therapeutic Targets for Alzheimer's Disease.
Islam Khan R, Nirzhor SSR, Rashid B. Islam Khan R, et al. Brain Sci. 2018 Aug 26;8(9):162. doi: 10.3390/brainsci8090162. Brain Sci. 2018. PMID: 30149687 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials