Detection of interleukin-8 in exudates from normal and inflamed human dental pulp tissues - PubMed (original) (raw)
Affiliations
- PMID: 11314344
Detection of interleukin-8 in exudates from normal and inflamed human dental pulp tissues
X Guo et al. Chin J Dent Res. 2000 May.
Abstract
Objective: The purpose of this study was to investigate the level of IL-8 in exudates clinically obtained from normal and inflamed human dental pulp tissues so as to reveal the possible relationship between IL-8 and pulpitis.
Methods: Samples of 2 microliters of pulpal exudate from each normal or clinically diagnosed as acute or chronic pulpitis teeth was obtained by filter paper strips and IL-8 level was measured by ELISA method.
Results: No IL-8 was detected in the samples from normal pulp, but significant amount of IL-8 appeared in inflamed pulp tissues, and the level of IL-8 in exudates of acute stage of pulpitis was higher than that of chronic stage (P < 0.01).
Conclusions: This study demonstrates that IL-8 is produced and accumulated in pulp inflammation and may play a role in the occurrence and development of human pulpitis.
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