Immunological adjuvants promote activated T cell survival via induction of Bcl-3 - PubMed (original) (raw)
Immunological adjuvants promote activated T cell survival via induction of Bcl-3
T C Mitchell et al. Nat Immunol. 2001 May.
Abstract
Injection of soluble protein antigen into animals causes abortive proliferation of the responding T cells. Immunological adjuvants boost T cell responses at least in part by increasing the survival of activated T cells during and after the initial proliferative phase of their clonal expansion. To understand how adjuvants promote T cell survival, we used gene microarrays to analyze gene expression in T cells activated either with antigen alone or in the presence of two different adjuvants. Among the genes whose expression was increased by both adjuvants was the IkappaB family member Bcl-3. Retroviral infection experiments showed that expression of Bcl-3 increased survival of activated T cells in vitro and in vivo. Adjuvants may therefore improve survival of activated T cells via induction of Bcl-3.
Comment in
- To live and let die.
Gerondakis S, Strasser A. Gerondakis S, et al. Nat Immunol. 2001 May;2(5):377-9. doi: 10.1038/87669. Nat Immunol. 2001. PMID: 11323685 No abstract available.
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