SAP controls T cell responses to virus and terminal differentiation of TH2 cells - PubMed (original) (raw)

K B Nguyen, G C Pien, N Wang, C Gullo, D Howie, M R Sosa, M J Edwards, P Borrow, A R Satoskar, A H Sharpe, C A Biron, C Terhorst

Affiliations

• PMID: 11323694
• DOI: 10.1038/87713

SAP controls T cell responses to virus and terminal differentiation of TH2 cells

C Wu et al. Nat Immunol. 2001 May.

Abstract

SH2D1A, which encodes signaling lymphocyte activation molecule (SLAM)-associated protein (SAP), is altered in patients with X-linked lymphoproliferative disease (XLP), a primary immunodeficiency. SAP-deficient mice infected with lymphocytic choriomeningitis virus had greatly increased numbers of CD8+ and CD4+ interferon-gamma-producing spleen and liver cells compared to wild-type mice. The immune responses of SAP-deficient mice to infection with Leishmania major together with in vitro studies showed that activated SAP-deficient T cells had an impaired ability to differentiate into T helper 2 cells. The aberrant immune responses in SAP-deficient mice show that SAP controls several distinct key T cell signal transduction pathways, which explains in part the complexity of the XLP phenotypes.

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Comment in

• Helper T cell differentiation: a role for SAP?
  Fields PE, Flavell RA. Fields PE, et al. Nat Immunol. 2001 May;2(5):382-4. doi: 10.1038/87679. Nat Immunol. 2001. PMID: 11323688 No abstract available.

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