Mutations in fibroblast growth factor receptor 2 and fibroblast growth factor receptor 3 genes associated with human gastric and colorectal cancers - PubMed (original) (raw)
. 2001 May 1;61(9):3541-3.
Affiliations
- PMID: 11325814
Mutations in fibroblast growth factor receptor 2 and fibroblast growth factor receptor 3 genes associated with human gastric and colorectal cancers
J H Jang et al. Cancer Res. 2001.
Abstract
Autosomal dominant disorders of skeletal and cranial development have been linked to fibroblast growth factor receptor (FGFR) 2 and FGFR3. Here we report two identical mutations in FGFR2 that cause craniosynostosis syndromes, Crouzon, Apert, and Pfeiffer in gastric carcinoma. A missense mutation (Ser267Pro) in exon IIIa and a splice site mutation (940-2A-->G) in exon IIIc were detected in gastric cancer patients. Interestingly, these heterozygous somatic mutations are identical to the germinal activating mutations in FGFR2 reported previously in craniosynostosis syndromes. In addition, the two novel mutations of FGFR3 in colorectal carcinomas were identified. All identified mutations occurred at highly conserved sequences, not only in the FGFR family of molecules, but also throughout evolution and clustered in the immunoglobulin-like loop-III domain, highlighting the functional importance of this domain. Our results indicate that FGFR2 and FGFR3, in addition to their potential role in skeletal dysplasias, play an important role in tumorigenesis.
Similar articles
- Description of a new mutation and characterization of FGFR1, FGFR2, and FGFR3 mutations among Brazilian patients with syndromic craniosynostoses.
Passos-Bueno MR, Sertié AL, Richieri-Costa A, Alonso LG, Zatz M, Alonso N, Brunoni D, Ribeiro SF. Passos-Bueno MR, et al. Am J Med Genet. 1998 Jul 7;78(3):237-41. Am J Med Genet. 1998. PMID: 9677057 - [From gene to disease; craniosynostosis syndromes due to FGFR2-mutation].
van Ravenswaaij-Arts CM, van den Ouweland AM, Hoogeboom AJ, Herbergs J, Pals G. van Ravenswaaij-Arts CM, et al. Ned Tijdschr Geneeskd. 2002 Jan 12;146(2):63-6. Ned Tijdschr Geneeskd. 2002. PMID: 11820058 Review. Dutch. - Identical mutations in three different fibroblast growth factor receptor genes in autosomal dominant craniosynostosis syndromes.
Bellus GA, Gaudenz K, Zackai EH, Clarke LA, Szabo J, Francomano CA, Muenke M. Bellus GA, et al. Nat Genet. 1996 Oct;14(2):174-6. doi: 10.1038/ng1096-174. Nat Genet. 1996. PMID: 8841188 - Fibroblast growth factor receptor 3 (FGFR3) transmembrane mutation in Crouzon syndrome with acanthosis nigricans.
Meyers GA, Orlow SJ, Munro IR, Przylepa KA, Jabs EW. Meyers GA, et al. Nat Genet. 1995 Dec;11(4):462-4. doi: 10.1038/ng1295-462. Nat Genet. 1995. PMID: 7493034 - Bad bones, absent smell, selfish testes: the pleiotropic consequences of human FGF receptor mutations.
Wilkie AO. Wilkie AO. Cytokine Growth Factor Rev. 2005 Apr;16(2):187-203. doi: 10.1016/j.cytogfr.2005.03.001. Epub 2005 Apr 1. Cytokine Growth Factor Rev. 2005. PMID: 15863034 Review.
Cited by
- Receptor tyrosine kinase gene expression profiling of orbital rhabdomyosarcoma unveils MET as a potential biomarker and therapeutic target.
Chauhan S, Sen S, Irshad K, Kashyap S, Pushker N, Meel R, Sharma MC. Chauhan S, et al. Hum Cell. 2024 Jan;37(1):297-309. doi: 10.1007/s13577-023-00993-5. Epub 2023 Nov 2. Hum Cell. 2024. PMID: 37914903 - Targeting FGFR Pathways in Gastrointestinal Cancers: New Frontiers of Treatment.
Ratti M, Orlandi E, Hahne JC, Vecchia S, Citterio C, Anselmi E, Toscani I, Ghidini M. Ratti M, et al. Biomedicines. 2023 Sep 27;11(10):2650. doi: 10.3390/biomedicines11102650. Biomedicines. 2023. PMID: 37893023 Free PMC article. Review. - Futibatinib, an Irreversible FGFR1-4 Inhibitor for the Treatment of FGFR-Aberrant Tumors.
Javle M, King G, Spencer K, Borad MJ. Javle M, et al. Oncologist. 2023 Nov 2;28(11):928-943. doi: 10.1093/oncolo/oyad149. Oncologist. 2023. PMID: 37390492 Free PMC article. Review. - The Significance of Human Papillomavirus Receptors Related Genetic Variants in Cervical Cancer Screening.
Xie H, Wei M, Yao L, Liu Y, Xie X, Li X. Xie H, et al. Microbiol Spectr. 2023 Aug 17;11(4):e0511722. doi: 10.1128/spectrum.05117-22. Epub 2023 Jun 26. Microbiol Spectr. 2023. PMID: 37358427 Free PMC article. - Aberrant Expression of FGFRL1 in Esophageal Cancer and Its Regulation by miR-107.
Sharma P, Kaushik V, Saraya A, Sharma R. Sharma P, et al. Asian Pac J Cancer Prev. 2023 Apr 1;24(4):1331-1341. doi: 10.31557/APJCP.2023.24.4.1331. Asian Pac J Cancer Prev. 2023. PMID: 37116156 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Medical
Molecular Biology Databases
Miscellaneous