Differentiation of embryonic stem cell lines generated from adult somatic cells by nuclear transfer - PubMed (original) (raw)

. 2001 Apr 27;292(5517):740-3.

doi: 10.1126/science.1059399.

Affiliations

• PMID: 11326103
• DOI: 10.1126/science.1059399

Differentiation of embryonic stem cell lines generated from adult somatic cells by nuclear transfer

T Wakayama et al. Science. 2001.

Abstract

Embryonic stem (ES) cells are fully pluripotent in that they can differentiate into all cell types, including gametes. We have derived 35 ES cell lines via nuclear transfer (ntES cell lines) from adult mouse somatic cells of inbred, hybrid, and mutant strains. ntES cells contributed to an extensive variety of cell types, including dopaminergic and serotonergic neurons in vitro and germ cells in vivo. Cloning by transfer of ntES cell nuclei could result in normal development of fertile adults. These studies demonstrate the full pluripotency of ntES cells.

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Comment in

• AIDS origins. Disputed AIDS theory dies its final death.
  Cohen J. Cohen J. Science. 2001 Apr 27;292(5517):615. doi: 10.1126/science.292.5517.615a. Science. 2001. PMID: 11330303 No abstract available.
• The ethical reasons for stem cell research.
  Lanza RP, Cibelli JB, West MD, Dorff E, Tauer C, Green RM. Lanza RP, et al. Science. 2001 May 18;292(5520):1299. doi: 10.1126/science.292.5520.1299b. Science. 2001. PMID: 11360981 No abstract available.

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