Conditioned blood reperfusion during angioplasty (CoBRA) treatment of acute myocardial infarction - PubMed (original) (raw)
Clinical Trial
. 2001 Mar:16 Suppl:39-49.
doi: 10.1177/026765910101600i106.
K S Kilgore, G A Ortolano, C L Gryboski, M A Qureshi, P Marcovitz, K B Naylor, J L Park, B Wenz, N Gikakis, R J Freedman Jr, B R Lucchesi, W W O'Neill
Affiliations
- PMID: 11334205
- DOI: 10.1177/026765910101600i106
Clinical Trial
Conditioned blood reperfusion during angioplasty (CoBRA) treatment of acute myocardial infarction
M B Patel et al. Perfusion. 2001 Mar.
Abstract
Acute myocardial infarct (MI) results in ischemia distal to lesions which puts heart muscle at risk for reperfusion injury (RI). Neutrophils, platelets and complement are putative mediators of RI. Recent advances in filtration technology provide integrated neutrophil and platelet removal together with complement-attenuating properties in a single blood-conditioning device. The present study characterizes the properties of a blood-conditioning filter and describes its clinical effect when used in conjunction with active hemoperfusion for acute MI. The filter reduces leukocytes by 99.9998 +/- 0.0002% (p<0.0001) and platelets by 99.9934 +/- 0.0069% (p<0.0001). Human plasma, derived from heparinized blood that was 'conditioned' by filtration, was studied using the Langendorff isolated rabbit heart preparation. The deposition of membrane attack complex and the resultant functional myocardial impairments [reflected in hemodynamic and biochemical measurements, including developed pressure, coronary blood flow, lymph-derived myocardial creatine kinase (CK)] are significantly attenuated by blood conditioning. Integration of the blood-conditioning filter into an active hemoperfusion system during primary percutaneous transluminal coronary angioplasty (PTCA) for acute MI (n=8) did not delay the procedure or cause any complications. Reperfusion of occluded coronary arteries with 300 cm3 of conditioned blood led to significant improvement in echocardiographic global wall motion scores (in standard deviations) following treatment (-1.64 +/- 0.18 to -1.45 +/- 0.15, p=0.02). Initial reperfusion of totally occluded coronary arteries with conditioned blood leads to acutely improved ventricular function. Collectively, these data provide a strong indication for continued investigation of conditioned blood reperfusion in angioplasty following acute MI for the long-term effect upon recovery of salvagable myocardium.
Similar articles
- [Attenuation of reperfusion phenomenon by reperfusion using leukocyte-depleted blood during direct percutaneous transluminal coronary angioplasty for acute myocardial infarction].
Watanabe S, Iseki H, Tanaka K, Ishibashi H, Tanaka K, Takei Y, Ejiri N. Watanabe S, et al. J Cardiol. 1999 Mar;33(3):145-52. J Cardiol. 1999. PMID: 10225194 Clinical Trial. Japanese. - Prevalence of late potentials after myocardial infarction treated with systemic thrombolysis or primary percutaneous transluminal coronary angioplasty.
Bruna C, Rossetti G, Vado A, Racca E, Steffenino G, Dellavalle A, Ribichini F, Ferrero V, Menardi E, Uslenghi E. Bruna C, et al. G Ital Cardiol. 1998 Jan;28(1):3-11. G Ital Cardiol. 1998. PMID: 9493040 Clinical Trial. - The reduction of infarct size--forty years of research.
Ferreira R. Ferreira R. Rev Port Cardiol. 2010 Jun;29(6):1037-53. Rev Port Cardiol. 2010. PMID: 20964114 Review. English, Portuguese. - An open design, multicentre, randomized trial of percutaneous transluminal coronary angioplasty versus stenting, with a heparin-coated stent, of totally occluded coronary arteries: rationale, trial design and baseline patient characteristics. Total Occlusion Study of Canada (TOSCA) Investigators.
Dzavik V, Carere RG, Teo KK, Knudtson ML, Marquis JF, Buller CE. Dzavik V, et al. Can J Cardiol. 1998 Jun;14(6):825-32. Can J Cardiol. 1998. PMID: 9676168 Review.
Cited by
- Ticagrelor attenuates myocardial ischaemia-reperfusion injury possibly through downregulating galectin-3 expression in the infarct area of rats.
Liu X, Gu Y, Liu Y, Zhang M, Wang Y, Hu L. Liu X, et al. Br J Clin Pharmacol. 2018 Jun;84(6):1180-1186. doi: 10.1111/bcp.13536. Epub 2018 Mar 9. Br J Clin Pharmacol. 2018. PMID: 29381821 Free PMC article. - Platelets, diabetes and myocardial ischemia/reperfusion injury.
Russo I, Penna C, Musso T, Popara J, Alloatti G, Cavalot F, Pagliaro P. Russo I, et al. Cardiovasc Diabetol. 2017 May 31;16(1):71. doi: 10.1186/s12933-017-0550-6. Cardiovasc Diabetol. 2017. PMID: 28569217 Free PMC article. Review. - Reperfusion injury following cerebral ischemia: pathophysiology, MR imaging, and potential therapies.
Pan J, Konstas AA, Bateman B, Ortolano GA, Pile-Spellman J. Pan J, et al. Neuroradiology. 2007 Feb;49(2):93-102. doi: 10.1007/s00234-006-0183-z. Epub 2006 Dec 20. Neuroradiology. 2007. PMID: 17177065 Free PMC article. Review. - Cardioprotective Properties of Human Platelets Are Lost in Uncontrolled Diabetes Mellitus: A Study in Isolated Rat Hearts.
Russo I, Femminò S, Barale C, Tullio F, Geuna S, Cavalot F, Pagliaro P, Penna C. Russo I, et al. Front Physiol. 2018 Jul 10;9:875. doi: 10.3389/fphys.2018.00875. eCollection 2018. Front Physiol. 2018. PMID: 30042694 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials