Early morphogenesis of the Caenorhabditis elegans pharynx - PubMed (original) (raw)
Comparative Study
. 2001 May 15;233(2):482-94.
doi: 10.1006/dbio.2001.0235.
Affiliations
- PMID: 11336509
- DOI: 10.1006/dbio.2001.0235
Free article
Comparative Study
Early morphogenesis of the Caenorhabditis elegans pharynx
M F Portereiko et al. Dev Biol. 2001.
Free article
Abstract
We investigated the cellular behaviors that accompany the early stages of pharyngeal morphogenesis in Caenorhabditis elegans. The embryonic pharynx develops from a ball of cells into a linear tube connected anteriorly to the buccal cavity and posteriorly to the midgut. By using GFP reporters localized to discrete subcellular regions, we show that pharyngeal morphogenesis can be divided into three stages: (1) lengthening of the nascent pharyngeal lumen by reorientation of apicobasal polarity of anterior pharyngeal cells ("Reorientation"), (2) formation of an epithelium by the buccal cavity cells, which mechanically couples the buccal cavity to the pharynx and anterior epidermis ("Epithelialization"), and (3) a concomitant movement of the pharynx anteriorly and the epidermis of the mouth posteriorly to bring the pharynx, buccal cavity, and mouth into close apposition ("Contraction"). Several models can account for these cellular behaviors, and we distinguish between them by physically or genetically ablating cells within the digestive tract. These studies provide the first description of how the pharynx primordium develops into an epithelial tube, and reveal that pharyngeal morphogenesis resembles aspects of mammalian kidney tubulogenesis.
Copyright 2001 Academic Press.
Similar articles
- Coordination of ges-1 expression between the Caenorhabditis pharynx and intestine.
Marshall SD, McGhee JD. Marshall SD, et al. Dev Biol. 2001 Nov 15;239(2):350-63. doi: 10.1006/dbio.2001.0442. Dev Biol. 2001. PMID: 11784040 - The third and fourth tropomyosin isoforms of Caenorhabditis elegans are expressed in the pharynx and intestines and are essential for development and morphology.
Anyanful A, Sakube Y, Takuwa K, Kagawa H. Anyanful A, et al. J Mol Biol. 2001 Oct 26;313(3):525-37. doi: 10.1006/jmbi.2001.5052. J Mol Biol. 2001. PMID: 11676537 - The zinc finger protein DIE-1 is required for late events during epithelial cell rearrangement in C. elegans.
Heid PJ, Raich WB, Smith R, Mohler WA, Simokat K, Gendreau SB, Rothman JH, Hardin J. Heid PJ, et al. Dev Biol. 2001 Aug 1;236(1):165-80. doi: 10.1006/dbio.2001.0315. Dev Biol. 2001. PMID: 11456452 - Development of Caenorhabditis elegans pharynx, with emphasis on its nervous system.
Pilon M, Mörck C. Pilon M, et al. Acta Pharmacol Sin. 2005 Apr;26(4):396-404. doi: 10.1111/j.1745-7254.2005.00070.x. Acta Pharmacol Sin. 2005. PMID: 15780187 Review.
Cited by
- Molecular characterization of the Caenorhabditis elegans ALP/Enigma gene alp-1.
McKeown CR, Han HF, Beckerle MC. McKeown CR, et al. Dev Dyn. 2006 Feb;235(2):530-8. doi: 10.1002/dvdy.20633. Dev Dyn. 2006. PMID: 16278882 Free PMC article. - The HLH-6 transcription factor regulates C. elegans pharyngeal gland development and function.
Smit RB, Schnabel R, Gaudet J. Smit RB, et al. PLoS Genet. 2008 Oct;4(10):e1000222. doi: 10.1371/journal.pgen.1000222. Epub 2008 Oct 17. PLoS Genet. 2008. PMID: 18927627 Free PMC article. - Polyphenism of a Novel Trait Integrated Rapidly Evolving Genes into Ancestrally Plastic Networks.
Casasa S, Biddle JF, Koutsovoulos GD, Ragsdale EJ. Casasa S, et al. Mol Biol Evol. 2021 Jan 23;38(2):331-343. doi: 10.1093/molbev/msaa235. Mol Biol Evol. 2021. PMID: 32931588 Free PMC article. - The twisted pharynx phenotype in C. elegans.
Axäng C, Rauthan M, Hall DH, Pilon M. Axäng C, et al. BMC Dev Biol. 2007 Jun 1;7:61. doi: 10.1186/1471-213X-7-61. BMC Dev Biol. 2007. PMID: 17540043 Free PMC article. - PHA-4/FoxA cooperates with TAM-1/TRIM to regulate cell fate restriction in the C. elegans foregut.
Kiefer JC, Smith PA, Mango SE. Kiefer JC, et al. Dev Biol. 2007 Mar 15;303(2):611-24. doi: 10.1016/j.ydbio.2006.11.042. Epub 2006 Dec 2. Dev Biol. 2007. PMID: 17250823 Free PMC article.