All in the family: the BTB/POZ, KRAB, and SCAN domains - PubMed (original) (raw)

Review

All in the family: the BTB/POZ, KRAB, and SCAN domains

T Collins et al. Mol Cell Biol. 2001 Jun.

No abstract available

Figures

FIG. 1

Three types of C2H2-type zinc finger-associated domains. The structure of representatives of the BTB/POZ (PLZF) (1, 30), KRAB (KOX1) (37, 38), and the SCAN (ZNF174) (50, 51) domain families is drawn schematically. The primary amino acid sequences of each of the domains, as well as information about the actual (BTB/POZ) or predicted secondary structures of the domains, are provided. The A and B subregions of the KRAB domain are also indicated.

FIG. 2

Alignment of the amino acid sequences of selected members of the SCAN domain family. To illustrate the remarkable homology characteristic of the SCAN domain, the amino acid sequences of the following SCAN domains are aligned: ZNF174 (GenBank accession number U31248); Zipro1 (also known as Ctfin51 [D10630], Ru49 [U41671], or Zfp38 [X63747]); MZF1 (also known as ZNF42 [AF161886]); ZNF202 (AF027219); ZNF213 (AF017433, also known as CR53); ZNF215 (AF056618); ZNF287 (AF217227); ZnF20 (AF011573, also known as p18 [Z21707]); murine NRIF (AJ242914); and murine PGC-2 (AF220501, also known as Leap1) and its human homolog, SDP1 (AF204271).

FIG. 3

Schematic diagram of four classes of SCAN domain family members. One representative of each of the four classes of SCAN family members discussed in the text is provided for comparison. The first class has an N-terminal SCAN domain and a variable number of C-terminal (C2H2)_x_-type zinc fingers [SCAN-(C2H2)_x_]. Found in this class are ZNF174 (51), and as described in the text, MZF1B (40) and Zipro1 (53). A second class of SCAN family members consists of the recently discovered group of isolated SCAN domain proteins. This group includes the mouse PGC-2, which has a partial SCAN domain (11) as well as the corresponding human homologs (43, 44). A third group of SCAN family members is composed of proteins predicted to have a SCAN-KRAB-(C2H2)x domain alignment, such as that encoded by the hypoalphalipoproteinemia susceptibility gene, ZNF202 (49); a BWS-associated gene, ZNF215 (3); ZNF213; which is linked with familial Mediterranean fever (13); and ZNF287, which has been associated with a deletion found in Smith-Magenis syndrome (NM020653). A final category consists of proteins with a predicted domain composition of KRAB-SCAN-KRAB-(C2H2)x, represented by the mouse protein NRIF, which interacts with the neurotrophin receptor (10).

References

1. Ahmad K F, Engel C K, Prive G G. Crystal structure of the BTB domain from PLZF. Proc Natl Acad Sci USA. 1998;95:12123–12128. - PMC - PubMed
1. Albagli O, Dhordain P, Deweindt C, Lecocq G, Leprince D. The BTB/POZ domain: a new protein-protein interaction motif common to DNA- and actin-binding proteins. Cell Growth Differ. 1995;6:1193–1198. - PubMed
1. Alders M, Ryan A, Hodges M, Bliek J, Feinberg A P, Privitera O, Westerveld A, Little P F R, Mannens M. Disruption of a novel imprinted zinc-finger gene, ZNF215, in Beckwith-Wiedemann syndrome. Am J Hum Genet. 2000;66:1473–1484. - PMC - PubMed
1. Babior B M, Matzner Y. The familial Mediterranean fever gene—cloned at last. N Engl J Med. 1997;337:1548–1549. - PubMed
1. Bardwell V J, Treisman R. The POZ domain: a conserved protein-protein interaction motif. Genes Dev. 1994;8:1664–1677. - PubMed

All in the family: the BTB/POZ, KRAB, and SCAN domains - PubMed (original) (raw)