Ubiquitin and the SCF(Grr1) ubiquitin ligase complex are involved in the signalling pathway activated by external amino acids in Saccharomyces cerevisiae - PubMed (original) (raw)
Ubiquitin and the SCF(Grr1) ubiquitin ligase complex are involved in the signalling pathway activated by external amino acids in Saccharomyces cerevisiae
F Bernard et al. FEBS Lett. 2001.
Free article
Abstract
In response to external amino acids, the permease-like sensor Ssy1 of Saccharomyces cerevisiae activates a pathway leading to transcriptional induction of several permease genes including AGP1 and PTR2. We previously reported that AGP1 induction requires Grr1, the F-box protein part of the SCF(Grr1) ubiquitin-ligase complex. We show here that ubiquitin, other components of SCF(Grr1) and the ubiquitin-conjugating enzyme Cdc34 are essential for AGP1 and PTR2 induction. This suggests that transduction to these genes of the amino acid signal generated by Ssy1 involves an SCF(Grr1)-catalysed ubiquitination step.
Similar articles
- Grr1 functions in the ubiquitin pathway in Saccharomyces cerevisiae through association with Skp1.
Kishi T, Seno T, Yamao F. Kishi T, et al. Mol Gen Genet. 1998 Jan;257(2):143-8. doi: 10.1007/s004380050633. Mol Gen Genet. 1998. PMID: 9491072 - Amino acid signaling in yeast: casein kinase I and the Ssy5 endoprotease are key determinants of endoproteolytic activation of the membrane-bound Stp1 transcription factor.
Abdel-Sater F, El Bakkoury M, Urrestarazu A, Vissers S, André B. Abdel-Sater F, et al. Mol Cell Biol. 2004 Nov;24(22):9771-85. doi: 10.1128/MCB.24.22.9771-9785.2004. Mol Cell Biol. 2004. PMID: 15509782 Free PMC article. - Cell cycle regulation by the ubiquitin pathway.
Pagano M. Pagano M. FASEB J. 1997 Nov;11(13):1067-75. doi: 10.1096/fasebj.11.13.9367342. FASEB J. 1997. PMID: 9367342 Review. - Ubiquitin-proteasome system as a factor that determine the sensitivity to methylmercury.
Hwang GW. Hwang GW. Yakugaku Zasshi. 2007 Mar;127(3):463-8. doi: 10.1248/yakushi.127.463. Yakugaku Zasshi. 2007. PMID: 17329932 Review.
Cited by
- Role of F-box Protein Cdc4 in Fungal Virulence and Sexual Reproduction of Cryptococcus neoformans.
Wu T, Fan CL, Han LT, Guo YB, Liu TB. Wu T, et al. Front Cell Infect Microbiol. 2022 Jan 11;11:806465. doi: 10.3389/fcimb.2021.806465. eCollection 2021. Front Cell Infect Microbiol. 2022. PMID: 35087766 Free PMC article. - Uncovering transcriptional regulation of metabolism by using metabolic network topology.
Patil KR, Nielsen J. Patil KR, et al. Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):2685-9. doi: 10.1073/pnas.0406811102. Epub 2005 Feb 14. Proc Natl Acad Sci U S A. 2005. PMID: 15710883 Free PMC article. - The N-terminal regulatory domain of Stp1p is modular and, fused to an artificial transcription factor, confers full Ssy1p-Ptr3p-Ssy5p sensor control.
Andréasson C, Ljungdahl PO. Andréasson C, et al. Mol Cell Biol. 2004 Sep;24(17):7503-13. doi: 10.1128/MCB.24.17.7503-7513.2004. Mol Cell Biol. 2004. PMID: 15314160 Free PMC article. - A phosphodegron controls nutrient-induced proteasomal activation of the signaling protease Ssy5.
Omnus DJ, Pfirrmann T, Andréasson C, Ljungdahl PO. Omnus DJ, et al. Mol Biol Cell. 2011 Aug 1;22(15):2754-65. doi: 10.1091/mbc.E11-04-0282. Epub 2011 Jun 8. Mol Biol Cell. 2011. PMID: 21653827 Free PMC article. - The prodomain of Ssy5 protease controls receptor-activated proteolysis of transcription factor Stp1.
Pfirrmann T, Heessen S, Omnus DJ, Andréasson C, Ljungdahl PO. Pfirrmann T, et al. Mol Cell Biol. 2010 Jul;30(13):3299-309. doi: 10.1128/MCB.00323-10. Epub 2010 Apr 26. Mol Cell Biol. 2010. PMID: 20421414 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Research Materials
Miscellaneous