Regulation of the eukaryotic cell cycle: molecular antagonism, hysteresis, and irreversible transitions - PubMed (original) (raw)

. 2001 May 21;210(2):249-63.

doi: 10.1006/jtbi.2001.2293.

Affiliations

Regulation of the eukaryotic cell cycle: molecular antagonism, hysteresis, and irreversible transitions

J J Tyson et al. J Theor Biol. 2001.

Abstract

In recent years, molecular biologists have uncovered a wealth of information about the proteins controlling cell growth and division in eukaryotes. The regulatory system is so complex that it defies understanding by verbal arguments alone. Quantitative tools are necessary to probe reliably into the details of cell cycle control. To this end, we convert hypothetical molecular mechanisms into sets of nonlinear ordinary differential equations and use standard analytical and numerical methods to study their solutions. First, we present a simple model of the antagonistic interactions between cyclin-dependent kinases and the anaphase promoting complex, which shows how progress through the cell cycle can be thought of as irreversible transitions (Start and Finish) between two stable states (G1 and S-G2-M) of the regulatory system. Then we add new pieces to the "puzzle" until we obtain reasonable models of the control systems in yeast cells, frog eggs, and cultured mammalian cells.

Copyright 2001 Academic Press.

PubMed Disclaimer

Publication types

MeSH terms

Substances

LinkOut - more resources