Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation - PubMed (original) (raw)

Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation

G M Doody et al. Nat Immunol. 2001 Jun.

Abstract

B and T lymphocytes develop normally in mice lacking the guanine nucleotide exchange factor Vav-2. However, the immune responses to type II thymus-independent antigen as well as the primary response to thymus-dependent (TD) antigen are defective. Vav-2-deficient mice are also defective in their ability to switch immunoglobulin class, form germinal centers and generate secondary immune responses to TD antigens. Mice lacking both Vav-1 and Vav-2 contain reduced numbers of B lymphocytes and display a maturational block in the development of mature B cells. B cells from Vav-1(-/-)Vav-2(-/-) mice respond poorly to antigen receptor triggering, both in terms of proliferation and calcium release. These studies show the importance of Vav-2 in humoral immune responses and B cell maturation.

PubMed Disclaimer

Comment in

Vav and the B cell signalosome.
DeFranco AL. DeFranco AL. Nat Immunol. 2001 Jun;2(6):482-4. doi: 10.1038/88669. Nat Immunol. 2001. PMID: 11376331 No abstract available.

Cited by

Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesis.
Hunter SG, Zhuang G, Brantley-Sieders D, Swat W, Cowan CW, Chen J. Hunter SG, et al. Mol Cell Biol. 2006 Jul;26(13):4830-42. doi: 10.1128/MCB.02215-05. Mol Cell Biol. 2006. PMID: 16782872 Free PMC article.
Loss of Vav2 proto-oncogene causes tachycardia and cardiovascular disease in mice.
Sauzeau V, Jerkic M, López-Novoa JM, Bustelo XR. Sauzeau V, et al. Mol Biol Cell. 2007 Mar;18(3):943-52. doi: 10.1091/mbc.e06-09-0877. Epub 2007 Jan 3. Mol Biol Cell. 2007. PMID: 17202406 Free PMC article.
Essential immunoregulatory role for BCAP in B cell development and function.
Yamazaki T, Takeda K, Gotoh K, Takeshima H, Akira S, Kurosaki T. Yamazaki T, et al. J Exp Med. 2002 Mar 4;195(5):535-45. doi: 10.1084/jem.20011751. J Exp Med. 2002. PMID: 11877477 Free PMC article.
Immunological function in mice lacking the Rac-related GTPase RhoG.
Vigorito E, Bell S, Hebeis BJ, Reynolds H, McAdam S, Emson PC, McKenzie A, Turner M. Vigorito E, et al. Mol Cell Biol. 2004 Jan;24(2):719-29. doi: 10.1128/MCB.24.2.719-729.2004. Mol Cell Biol. 2004. PMID: 14701744 Free PMC article.
Vav family proteins are required for optimal regulation of PLCgamma2 by integrin alphaIIbbeta3.
Pearce AC, McCarty OJ, Calaminus SD, Vigorito E, Turner M, Watson SP. Pearce AC, et al. Biochem J. 2007 Feb 1;401(3):753-61. doi: 10.1042/BJ20061508. Biochem J. 2007. PMID: 17054426 Free PMC article.

Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation - PubMed (original) (raw)