A non-sense mutation in Cd36 gene is associated with protection from severe malaria - PubMed (original) (raw)
A non-sense mutation in Cd36 gene is associated with protection from severe malaria
A Pain et al. Lancet. 2001.
Abstract
We sought genetic evidence for the importance of host-parasite interactions involving CD36 in severe malaria. We identified a non-sense mutation in Cd36 gene and looked at the influence of this mutation on the outcome of malaria infection in 693 African children with severe malaria and a similar number of ethnically matched controls. We showed that heterozygosity for this mutation is associated with protection from severe disease (OR 0.74, 95% CI 0.55-0.99; p=0.036). These findings suggest that this Cd36 mutation might have a complex effect on malaria infection by decreasing parasite sequestration, and also by decreasing host immune responses.
Comment in
- A non-sense mutation and protection from severe malaria.
Konotey-Ahulu FI. Konotey-Ahulu FI. Lancet. 2001 Sep 15;358(9285):927-8. doi: 10.1016/S0140-6736(01)06059-7. Lancet. 2001. PMID: 11575375 No abstract available. - A non-sense mutation and protection from severe malaria.
Rogerson S, Molyneux M, Taylor T. Rogerson S, et al. Lancet. 2001 Sep 15;358(9285):928. doi: 10.1016/S0140-6736(01)06061-5. Lancet. 2001. PMID: 11575376 No abstract available.
Similar articles
- CD36 T188G gene polymorphism and severe falciparum malaria in India.
Das A, Das TK, Sahu U, Das BP, Kar SK, Ranjit MR. Das A, et al. Trans R Soc Trop Med Hyg. 2009 Jul;103(7):687-90. doi: 10.1016/j.trstmh.2008.11.015. Epub 2009 Jan 10. Trans R Soc Trop Med Hyg. 2009. PMID: 19136129 - A non-sense mutation and protection from severe malaria.
Konotey-Ahulu FI. Konotey-Ahulu FI. Lancet. 2001 Sep 15;358(9285):927-8. doi: 10.1016/S0140-6736(01)06059-7. Lancet. 2001. PMID: 11575375 No abstract available. - Plasmodium falciparum malaria and the immunogenetics of ABO, HLA, and CD36 (platelet glycoprotein IV).
Cserti-Gazdewich CM, Mayr WR, Dzik WH. Cserti-Gazdewich CM, et al. Vox Sang. 2011 Jan;100(1):99-111. doi: 10.1111/j.1423-0410.2010.01429.x. Vox Sang. 2011. PMID: 21175660 Review. - CD36 c.1264 T>G null mutation impairs acquisition of IgG antibodies to Plasmodium falciparum MSP1₁₉ antigen and is associated with higher malaria incidences in Tanzanian children.
Kajeguka D, Mwanziva C, Daou M, Ndaro A, Matondo S, Mbugi E, Dolmans W, Chilongola J. Kajeguka D, et al. Scand J Immunol. 2012 Mar;75(3):355-60. doi: 10.1111/j.1365-3083.2011.02661.x. Scand J Immunol. 2012. PMID: 22050542 - Malaria blood-stage infection and its control by the immune system.
Perlmann P, Troye-Blomberg M. Perlmann P, et al. Folia Biol (Praha). 2000;46(6):210-8. Folia Biol (Praha). 2000. PMID: 11140853 Review.
Cited by
- The host genetic diversity in malaria infection.
de Mendonça VR, Goncalves MS, Barral-Netto M. de Mendonça VR, et al. J Trop Med. 2012;2012:940616. doi: 10.1155/2012/940616. Epub 2012 Dec 13. J Trop Med. 2012. PMID: 23316245 Free PMC article. - CD36 polymorphism is associated with protection from cerebral malaria.
Omi K, Ohashi J, Patarapotikul J, Hananantachai H, Naka I, Looareesuwan S, Tokunaga K. Omi K, et al. Am J Hum Genet. 2003 Feb;72(2):364-74. doi: 10.1086/346091. Epub 2002 Dec 27. Am J Hum Genet. 2003. PMID: 12506336 Free PMC article. - Marked variation in prevalence of malaria-protective human genetic polymorphisms across Uganda.
Walakira A, Tukwasibwe S, Kiggundu M, Verra F, Kakeeto P, Ruhamyankaka E, Drakeley C, Dorsey G, Kamya MR, Nsobya SL, Rosenthal PJ. Walakira A, et al. Infect Genet Evol. 2017 Nov;55:281-287. doi: 10.1016/j.meegid.2017.09.021. Epub 2017 Sep 19. Infect Genet Evol. 2017. PMID: 28939159 Free PMC article. - Variations in host genes encoding adhesion molecules and susceptibility to falciparum malaria in India.
Sinha S, Qidwai T, Kanchan K, Anand P, Jha GN, Pati SS, Mohanty S, Mishra SK, Tyagi PK, Sharma SK; Indian Genome Variation Consortium; Venkatesh V, Habib S. Sinha S, et al. Malar J. 2008 Dec 4;7:250. doi: 10.1186/1475-2875-7-250. Malar J. 2008. PMID: 19055786 Free PMC article. - Adipose tissue parasite sequestration drives leptin production in mice and correlates with human cerebral malaria.
Mejia P, Treviño-Villarreal JH, De Niz M, Meibalan E, Longchamp A, Reynolds JS, Turnbull LB, Opoka RO, Roussilhon C, Spielmann T, Ozaki CK, Heussler VT, Seydel KB, Taylor TE, John CC, Milner DA, Marti M, Mitchell JR. Mejia P, et al. Sci Adv. 2021 Mar 24;7(13):eabe2484. doi: 10.1126/sciadv.abe2484. Print 2021 Mar. Sci Adv. 2021. PMID: 33762334 Free PMC article.