Insulin resistance is increased by transdermal estrogen therapy in postmenopausal women with cardiac syndrome X - PubMed (original) (raw)
Clinical Trial
doi: 10.1159/000047340.
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- PMID: 11385189
- DOI: 10.1159/000047340
Clinical Trial
Insulin resistance is increased by transdermal estrogen therapy in postmenopausal women with cardiac syndrome X
A R Assali et al. Cardiology. 2001.
Abstract
Estrogen has been reported to have both short- and long-term effects on the cardiovascular system. However, it remains to be examined how short-term transdermal estrogen therapy (TET) affects insulin sensitivity (SI) in patients with cardiac syndrome X (CSX), who are characterized by elevated insulin resistance. SI was assessed in a randomized, double-blind, placebo-controlled crossover study by minimal model analysis in seven postmenopausal women with CSX treated by TET. SI decreased by 32 +/- 8.3%, from 5.94 +/- 1.14 at baseline to 3.61 +/- 0.40 [(10(-4) x min(-1))/(microU/ml)] during TET (p = 0.03). Time to the onset of symptoms increased from 414.2 +/- 51.0 s at baseline to 450.0 +/- 53.2 s (p = 0.04). We conclude that TET increases SI in postmenopausal women with CSX. This effect is unrelated to the beneficial anti-ischemic effects on exercise duration.
Copyright 2001 S. Karger AG, Basel.
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