Evidence that RME-1, a conserved C. elegans EH-domain protein, functions in endocytic recycling - PubMed (original) (raw)

Evidence that RME-1, a conserved C. elegans EH-domain protein, functions in endocytic recycling

B Grant et al. Nat Cell Biol. 2001 Jun.

Abstract

In genetic screens for new endocytosis genes in Caenorhabditis elegans we identified RME-1, a member of a conserved class of Eps15-homology (EH)-domain proteins. Here we show that RME-1 is associated with the periphery of endocytic organelles, which is consistent with a direct role in endocytic transport. Endocytic defects in rme-1 mutants indicate that the protein is likely to have a function in endocytic recycling. Evidence from studies of mammalian RME-1 also points to a function for RME-1 in recycling, specifically in the exit of membrane proteins from recycling endosomes. These studies show a conserved function in endocytic recycling for the RME-1 family of EH proteins.

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Comment in

• Round-trip ticket: recycling to the plasma membrane requires RME-1.
  Wendland B. Wendland B. Nat Cell Biol. 2001 Jun;3(6):E133-5. doi: 10.1038/35078592. Nat Cell Biol. 2001. PMID: 11389449 No abstract available.

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• R24 OD010943/OD/NIH HHS/United States
• F32 GM019167-01/GM/NIGMS NIH HHS/United States
• F32 GM019167-02/GM/NIGMS NIH HHS/United States
• R24 RR012596/RR/NCRR NIH HHS/United States
• F32 GM019167/GM/NIGMS NIH HHS/United States

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