Evidence that human cardiac myocytes divide after myocardial infarction - PubMed (original) (raw)
. 2001 Jun 7;344(23):1750-7.
doi: 10.1056/NEJM200106073442303.
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- PMID: 11396441
- DOI: 10.1056/NEJM200106073442303
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Evidence that human cardiac myocytes divide after myocardial infarction
A P Beltrami et al. N Engl J Med. 2001.
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Abstract
Background: The scarring of the heart that results from myocardial infarction has been interpreted as evidence that the heart is composed of myocytes that are unable to divide. However, recent observations have provided evidence of proliferation of myocytes in the adult heart. Therefore, we studied the extent of mitosis among myocytes after myocardial infarction in humans.
Methods: Samples from the border of the infarct and from areas of the myocardium distant from the infarct were obtained from 13 patients who had died 4 to 12 days after infarction. Ten normal hearts were used as controls. Myocytes that had entered the cell cycle in preparation for cell division were measured by labeling of the nuclear antigen Ki-67, which is associated with cell division. The fraction of myocyte nuclei that were undergoing mitosis was determined, and the mitotic index (the ratio of the number of nuclei undergoing mitosis to the number not undergoing mitosis) was calculated. The presence of mitotic spindles, contractile rings, karyokinesis, and cytokinesis was also recorded.
Results: In the infarcted hearts, Ki-67 expression was detected in 4 percent of myocyte nuclei in the regions adjacent to the infarcts and in 1 percent of those in regions distant from the infarcts. The reentry of myocytes into the cell cycle resulted in mitotic indexes of 0.08 percent and 0.03 percent, respectively, in the zones adjacent to and distant from the infarcts. Events characteristic of cell division--the formation of the mitotic spindles, the formation of contractile rings, karyokinesis, and cytokinesis--were identified; these features demonstrated that there was myocyte proliferation after myocardial infarction.
Conclusions: Our results challenge the dogma that the adult heart is a postmitotic organ and indicate that the regeneration of myocytes may be a critical component of the increase in muscle mass of the myocardium.
Comment in
- High hopes for the heart.
Rosenthal N. Rosenthal N. N Engl J Med. 2001 Jun 7;344(23):1785-7. doi: 10.1056/NEJM200106073442311. N Engl J Med. 2001. PMID: 11396449 No abstract available. - Evidence that human cardiac myocytes divide after myocardial infarction.
Raman SV, Cooke GE, Binkley PF. Raman SV, et al. N Engl J Med. 2001 Oct 11;345(15):1130-1. doi: 10.1056/NEJM200110113451513. N Engl J Med. 2001. PMID: 11596596 No abstract available. - Evidence that human cardiac myocytes divide after myocardial infarction.
Katz AM. Katz AM. N Engl J Med. 2001 Oct 11;345(15):1130; author reply 1131. N Engl J Med. 2001. PMID: 11596597 No abstract available. - Evidence that human cardiac myocytes divide after myocardial infarction.
Goldman BI, Wurzel J. Goldman BI, et al. N Engl J Med. 2001 Oct 11;345(15):1131. doi: 10.1056/NEJM200110113451514. N Engl J Med. 2001. PMID: 11596598 No abstract available. - Intramyocardial transplantation of endothelial progenitor cells and erythropoietin: a new scope for the treatment of cardiovascular disease.
Dimitrova KR, Leitman IM. Dimitrova KR, et al. J Surg Res. 2013 Aug;183(2):550-2. doi: 10.1016/j.jss.2012.05.010. Epub 2012 May 23. J Surg Res. 2013. PMID: 22656040 No abstract available.
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