How does calcium trigger neurotransmitter release? - PubMed (original) (raw)
Review
How does calcium trigger neurotransmitter release?
G J Augustine. Curr Opin Neurobiol. 2001 Jun.
Abstract
Recent work has established that different geometric arrangements of calcium channels are found at different presynaptic terminals, leading to a wide spectrum of calcium signals for triggering neurotransmitter release. These calcium signals are apparently transduced by synaptotagmins - calcium-binding proteins found in synaptic vesicles. New biochemical results indicate that all synaptotagmins undergo calcium-dependent interactions with membrane lipids and a number of other presynaptic proteins, but which of these interactions is responsible for calcium-triggered transmitter release remains unclear.
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