Identification of sequence selective receptors for peptides with a carboxylic acid terminus - PubMed (original) (raw)
Identification of sequence selective receptors for peptides with a carboxylic acid terminus
T Braxmeier et al. Chemistry. 2001.
Abstract
Split-and-mix libraries of resin-bound "tweezer" receptors have been prepared and screened to identify receptors for dye-labelled tripeptides. The receptors incorporate a diamidopyridine unit to serve as a specific recognition site for the CO2H group, leading to strong and selective receptors for peptide guests with a CO2H terminus. The role of the dye-label, attached to the peptide guest to allow visualisation of selective recognition events in the screening experiments, has also been examined and was found to have a significant influence on the binding selectivities.
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