Genetical genomics: the added value from segregation - PubMed (original) (raw)
Genetical genomics: the added value from segregation
R C Jansen et al. Trends Genet. 2001 Jul.
Abstract
The recent successes of genome-wide expression profiling in biology tend to overlook the power of genetics. We here propose a merger of genomics and genetics into 'genetical genomics'. This involves expression profiling and marker-based fingerprinting of each individual of a segregating population, and exploits all the statistical tools used in the analysis of quantitative trait loci. Genetical genomics will combine the power of two different worlds in a way that is likely to become instrumental in the further unravelling of metabolic, regulatory and developmental pathways.
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